6-OHDA-Induced Changes in Colonic Segment Contractility in the Rat Model of Parkinson’s Disease

Figure 4

Proximal colon contractile responses to electrical field stimulation (EFS) and methacholine. EFS in the circular strips showed a trend for increased contractile responses in the 6-OHDA () as compared with Sham animals (; a), whereas the proximal colon segments displayed a non-significant decreased response in the 6-OHDA animals () compared with Sham animals (; e). The methacholine-induced contraction in the circular strips (b: 6-OHDA, ; Sham, ) and the segments (f: 6-OHDA, ; Sham, ) was not significantly changed between the groups. No changes were observed in the longitudinal strips either by EFS (c; 6-OHDA, and Sham, ) or methacholine-induced contraction (d; in each group); two-way ANOVAs a: group , ; (e) group , .