6-OHDA-Induced Changes in Colonic Segment Contractility in the Rat Model of Parkinson’s Disease

Figure 6

Spontaneous contractions in distal and proximal colon. No changes were observed between the groups in distal colon in either circular strips (a: Sham ; 6-OHDA, ), longitudinal strips (b: Sham ; 6-OHDA, ) or segments (c: Sham 6-OHDA, ). In the proximal colon segments (f) an increased spontaneous contractility after the high K⁺ Krebs activation were observed in the 6-OHDA () as compared with Sham animals (). This was however, not observed in either circular (d: Sham , 6-OHDA, ), or longitudinal strips (e: Sham ; 6-OHDA, ) of the proximal colon. * = Significant difference from Sham group; Mann–Whitney U test (f) .