6-OHDA-Induced Changes in Colonic Segment Contractility in the Rat Model of Parkinson’s Disease

Table 2

Tissue strip and segment weights (mg) and high K⁺ Krebs response (mN mg⁻¹) in Sham-operated, 6-OHDA lesioned, and Healthy animals.

		Tissue weight (mg)					High K^+ response per tissue weight (mN mg^−1)
		Sham	6-OHDA	-Value^a	Healthy	-Value^b	Sham	6-OHDA	-Value^a	Healthy	-Value^b
Distal colon	Circular	()	()	0.390	()	0.542	()	()	0.839	()	0.618
	Longitudinal	()	()	0.261	()	0.541	()	()	0.209	()	0.837
	Segment	()	()	0.218	()	0.0636	()	()	0.0010*	()	0.0141*
	Segment (inverted)	()	()	0.104	—	—	()	()	0.122	—	—
Proximal colon	Circular	()	()	0.0896	()	0.827	()	()	0.105	()	0.0422*
	Longitudinal	()	()	0.604	()	0.552	()	()	0.315	()	0.602
	Segment	()	()	0.260	()	0.796	()	()	0.0028*	()	0.0614
Distal ileum	Segment	()	()	0.0734	()	0.418	()	()	0.842	()	0.686

^aUnpaired t-test between Sham and 6-OHDA groups; * and bold = significant differences between 6-OHDA and Sham groups.
^bUnpaired t-test between Sham and Healthy animals; * and bold = significant differences between Sham and Healthy groups.