Gastroenterology Research and Practice

Novel Molecular Targets in Malignant Diseases of Digestive System 2014


Publishing date
06 Feb 2015
Status
Published
Submission deadline
19 Sep 2014

Lead Editor

1Nanjing University, Nanjing, China

2New York Medical College, Valhalla, USA

3Zhejiang University School of Medicine, Hangzhou, China


Novel Molecular Targets in Malignant Diseases of Digestive System 2014

Description

Malignant diseases of digestive system represent a significant health problem worldwide. In recent years, the advances in mechanisms of digestive system cancers have revealed multiple molecular pathways participating in the process of carcinogenesis, angiogenesis, tumor microenvironment, metastasis, and so forth. These findings lead to the innovation of novel molecular-targeted therapeutics including multikinase inhibitor sorafenib for hepatocellular carcinoma, c-kit inhibitor imatinib for gastrointestinal stromal tumor, and VEGF-targeting bevacizumab for colorectal cancer, which have significantly improved the prognosis of these malignancies. Upcoming research on potential molecular targets in digestive system tumors will have distinguished significance in novel drug development and may have a direct impact on clinical practice.

We are particularly interested in studies reporting novel molecular targets in digestive system cancers with relevance to carcinogenesis, tumor malignant behavior, prognosis prediction, or monitoring of therapy. Manuscripts delineating potential molecular targeting compounds or biochemical intervention with mechanism discussion would be of great interest. Reviews that summarize recent improvements in novel molecular targets and novel therapeutic innovations in malignancies of digestive system are also welcome.

Potential topics include, but are not limited to:

  • Molecular targets in carcinogenesis
  • Molecular targets in metastasis (cancer cell motility, invasion, epithelial to mesenchymal transition, etc.)
  • Molecular targets in tumor microenvironment (tumor immunity, tumor-associated stromal cells, messengers between cancer cell and microenvironment, etc.)
  • Molecular targets in cancer-associated inflammation
  • Clinical significance of molecular pathways
  • Novel targeted compounds and biochemical interventions

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 634740
  • - Editorial

Novel Molecular Targets in Malignant Diseases of Digestive System 2014

Chunping Jiang | Youmin Wu | ... | Zhongxia Wang
  • Special Issue
  • - Volume 2015
  • - Article ID 946359
  • - Research Article

Correlations of Human Epithelial Growth Factor Receptor 2 Overexpression with MUC2, MUC5AC, MUC6, p53, and Clinicopathological Characteristics in Gastric Cancer Patients with Curative Resection

Kwang Kuk Park | Song I Yang | ... | Yeon Myeong Shin
  • Special Issue
  • - Volume 2015
  • - Article ID 796380
  • - Review Article

Therapeutic Targeting of Fibroblast Growth Factor Receptors in Gastric Cancer

Mikito Inokuchi | Yoshitaka Fujimori | ... | Kazuyuki Kojima
  • Special Issue
  • - Volume 2015
  • - Article ID 572171
  • - Research Article

TLR3 Plays Significant Roles against HBV-Associated HCC

Xiao-lan Chen | Yu-yin Xu | ... | Yin Shen
  • Special Issue
  • - Volume 2015
  • - Article ID 957574
  • - Research Article

Inhibitory Effect of Endostar on Specific Angiogenesis Induced by Human Hepatocellular Carcinoma

Qing Ye | Shukui Qin | ... | Xiaojin Yin
  • Special Issue
  • - Volume 2015
  • - Article ID 753903
  • - Research Article

KRAS and BRAF Mutation Detection: Is Immunohistochemistry a Possible Alternative to Molecular Biology in Colorectal Cancer?

Nicolas Piton | Francesco Borrini | ... | Jean-Christophe Sabourin
  • Special Issue
  • - Volume 2015
  • - Article ID 764163
  • - Review Article

Effects of Two Common Polymorphisms rs2910164 in miR-146a and rs11614913 in miR-196a2 on Gastric Cancer Susceptibility

Qing Ni | Anlai Ji | ... | Xinnong Liu
  • Special Issue
  • - Volume 2015
  • - Article ID 568981
  • - Research Article

Molecular Mechanism of Local Drug Delivery with Paclitaxel-Eluting Membranes in Biliary and Pancreatic Cancer: New Application for an Old Drug

Sookhee Bang | Sung Ill Jang | ... | Dong Ki Lee
Gastroenterology Research and Practice
 Journal metrics
Acceptance rate29%
Submission to final decision96 days
Acceptance to publication35 days
CiteScore1.940
Impact Factor1.825
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