Faecal microbiota transplantation (FMT) has been used for the treatment of dysbiosis related diseases beyond recurrent Clostridioides difficile infection (CDI). The latest progress on FMT mainly involves washed microbiota transplantation (WMT), newly developed delivery of microbiota, expanded indications, and updated adverse events of FMT.

However, the regulation, laboratory methods, clinical work-flow, and clinical application of FMT varies between different countries and areas. These undetermined factors, such as manual preparation of faecal maters or washed microbiota preparation, lower or higher doses, capsulised delivery or delivery by transendoscopic enteral tube, delivery-related adverse events or microbiota-related adverse events, can all contribute to variations in findings, and therefore it is essential to focus on cutting-edge research in this field.

In this Special Issue submission of original papers, case reports, review articles, or opinions concerning the topics mentioned above and related fields are welcomed. All accepted articles will be published ahead of time. We invite researchers to contribute original research and review articles exploring manual FMT or WMT in practice and animal studies. We are particularly interested in controlled trials, high-quality clinical series reports, safety studies, systematic reviews, and meta-analyses.

Potential topics include but are not limited to the following:

• Pilot evaluation of FMT on conditions beyond CDI, such as inflammation, bowel disease, irritable bowel disease, microbiota-gut-brain axis, and diabetes
• Creative delivery studies on FMT
• Safety studies from real world or animal studies on FMT
• The cross-talk of interactive actions between microbiota and host
• Methods of preparing and transporting faecal microbiota
• Ethical concerns on FMT, the patients’ education on FMT related technologies