Gastroenterology Research and Practice

Novel Molecular Targets in Malignant Diseases of Digestive System


Publishing date
20 Dec 2013
Status
Published
Submission deadline
02 Aug 2013

Lead Editor

1Department of Hepatobiliary Surgery, Affiliated Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu, China

2Transplantation Surgery Division, University of Arkansas for Medical Sciences, Little Rock, AR, USA

3Department of Transplantation and Hepatic Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, China

4Harvard Medical School, Boston, MA, USA


Novel Molecular Targets in Malignant Diseases of Digestive System

Description

Malignant diseases of digestive system represent a significant health problem worldwide. In recent years, the advances in mechanisms of digestive system cancers have revealed multiple molecular pathways participating in the process of carcinogenesis, angiogenesis, tumor microenvironment, metastasis, and so forth. These findings lead to the innovation of novel molecular-targeted therapeutics including multikinase inhibitor sorafenib for hepatocellular carcinoma, c-kit inhibitor imatinib for gastrointestinal stromal tumor, and VEGF-targeting bevacizumab for colorectal cancer, which have significantly improved the prognosis of these malignancies. Upcoming research on potential molecular targets in digestive system tumors will have distinguished significance in novel drug development and may have a direct impact on clinical practice.

We are particularly interested in studies reporting novel molecular targets in digestive system cancers with relevance to carcinogenesis, tumor malignant behavior, prognosis prediction, or monitoring of therapy. Manuscripts delineating potential molecular targeting compounds or biochemical intervention with mechanism discussion would be of great interest. Reviews that summarize recent improvements in novel molecular targets and novel therapeutic innovations in malignancies of digestive system are also welcome. Potential topics include, but are not limited to:

  • Molecular targets in carcinogenesis
  • Molecular targets in metastasis (cancer cell motility, invasion, epithelial to mesenchymal transition, etc.)
  • Molecular targets in tumor microenvironment (tumor immunity, tumor-associated stromal cells, messengers between cancer cell and microenvironment, etc.)
  • Molecular targets in cancer-associated inflammation
  • Clinical significance of molecular pathways
  • Novel targeted compounds and biochemical interventions

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/grp/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/grp/mdds/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2013
  • - Article ID 568280
  • - Editorial

Novel Molecular Targets in Malignant Diseases of Digestive System

Chunping Jiang | Youmin Wu | ... | Qin Huang
  • Special Issue
  • - Volume 2013
  • - Article ID 703163
  • - Research Article

Mast Cells Positive to Tryptase and c-Kit Receptor Expressing Cells Correlates with Angiogenesis in Gastric Cancer Patients Surgically Treated

Michele Ammendola | Rosario Sacco | ... | Girolamo Ranieri
  • Special Issue
  • - Volume 2013
  • - Article ID 109759
  • - Research Article

LEPREL1 Expression in Human Hepatocellular Carcinoma and Its Suppressor Role on Cell Proliferation

Jianguo Wang | Xiao Xu | ... | Shusen Zheng
  • Special Issue
  • - Volume 2013
  • - Article ID 675429
  • - Review Article

PP2A-Mediated Anticancer Therapy

Weibo Chen | Zhongxia Wang | ... | Yitao Ding
  • Special Issue
  • - Volume 2013
  • - Article ID 685150
  • - Research Article

Study of RNA Interference Targeting NET-1 Combination with Sorafenib for Hepatocellular Carcinoma Therapy In Vitro and In Vivo

Song He | Ying-ze Wei | ... | Li Chen
  • Special Issue
  • - Volume 2013
  • - Article ID 380193
  • - Research Article

Significance of Glutathione Peroxidase 1 and Caudal-Related Homeodomain Transcription Factor in Human Gastric Adenocarcinoma

Jing Jing Han | De Rong Xie | ... | Hai Gang Li
  • Special Issue
  • - Volume 2013
  • - Article ID 634929
  • - Review Article

Indirect Comparison Showed Survival Benefit from Adjuvant Chemoradiotherapy in Completely Resected Gastric Cancer with D2 Lymphadenectomy

Qiong Yang | Ying Wei | ... | De-Rong Xie
  • Special Issue
  • - Volume 2013
  • - Article ID 782581
  • - Research Article

Expression of Potential Cancer Stem Cell Marker ABCG2 is Associated with Malignant Behaviors of Hepatocellular Carcinoma

Guang Zhang | Zhongxia Wang | ... | Chunping Jiang
  • Special Issue
  • - Volume 2013
  • - Article ID 719202
  • - Review Article

Associations of miR-499 and miR-34b/c Polymorphisms with Susceptibility to Hepatocellular Carcinoma: An Evidence-Based Evaluation

Zhongxia Wang | Junhua Wu | ... | Yitao Ding
  • Special Issue
  • - Volume 2013
  • - Article ID 804128
  • - Clinical Study

MicroRNA-429 Modulates Hepatocellular Carcinoma Prognosis and Tumorigenesis

Xiao-Ying Huang | Jin-Guang Yao | ... | Xi-Dai Long
Gastroenterology Research and Practice
 Journal metrics
Acceptance rate25%
Submission to final decision63 days
Acceptance to publication29 days
CiteScore3.400
Impact Factor1.806
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