Table of Contents
Hepatitis Research and Treatment
Volume 2011 (2011), Article ID 363205, 10 pages
http://dx.doi.org/10.1155/2011/363205
Research Article

Etiology and Viral Genotype in Patients with End-Stage Liver Diseases admitted to a Hepatology Unit in Colombia

1Grupo de Gastrohepatología, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia
2Instituto Tecnológico Metropolitano (ITM), Institución Universitaria Adscrita a la Alcaldía de Medellín, Medellín 549 59, Colombia
3Laboratorio de Virología Molecular, CMBC, Instituto Venezolano de Investigaciones Científicas, Apdo. 20632, Caracas 1020A, Venezuela, Caracas, Venezuela
4Unidad de Hepatología y Trasplante Hepático, Hospital Pablo Tobón Uribe (HPTU), Calle 78B 69-240, Medellín, Colombia
5Department of Virology, Swedish Institute for Infectious Disease Control, 171 82 Solna, Sweden

Received 21 March 2011; Accepted 21 July 2011

Academic Editor: Isabelle Chemin

Copyright © 2011 Fabian Cortes-Mancera et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. F. Perz, G. L. Armstrong, L. A. Farrington, Y. J. F. Hutin, and B. P. Bell, “The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide,” Journal of Hepatology, vol. 45, no. 4, pp. 529–538, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. D. Lavanchy, “Hepatitis B virus epidemiology, disease burden, treatment, arid current and emerging prevention and control measures,” Journal of Viral Hepatitis, vol. 11, no. 2, pp. 97–107, 2004. View at Publisher · View at Google Scholar · View at Scopus
  3. Globocan, “2002 World Health Organization,” http://www-dep.iarc.fr/.
  4. C. J. Liu, B. F. Chen, P. J. Chen et al., “Role of hepatitis B viral load and basal core promoter mutation in hepatocellular carcinoma in hepatitis B carriers,” Journal of Infectious Diseases, vol. 193, no. 9, pp. 1258–1265, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. C. J. Liu and J. H. Kao, “Hepatitis B virus-related hepatocellular carcinoma: epidemiology and pathogenic role of viral factors,” Journal of the Chinese Medical Association, vol. 70, no. 4, pp. 141–145, 2007. View at Google Scholar · View at Scopus
  6. D. Y. K. But, C. L. Lai, and M. F. Yuen, “Natural history of hepatitis-related hepatocellular carcinoma,” World Journal of Gastroenterology, vol. 14, no. 11, pp. 1652–1656, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. C. M. Lee, C. Hung, S. N. Lu, and C. S. Changchien, “Hepatitis C virus genotypes: clinical relevance and therapeutic implications,” Chang Gung Medical Journal, vol. 31, no. 1, pp. 16–25, 2008. View at Google Scholar · View at Scopus
  8. C. L. Lin and J. H. Kao, “Hepatitis B viral factors and clinical outcomes of chronic hepatitis B,” Journal of Biomedical Science, vol. 15, no. 2, pp. 137–145, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. J. H. Kao, P. J. Chen, M. Y. Lai, and D. S. Chen, “Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B,” Gastroenterology, vol. 118, no. 3, pp. 554–559, 2000. View at Google Scholar · View at Scopus
  10. A. Tsubota, Y. Arase, F. Ren, H. Tanaka, K. Ikeda, and H. Kumada, “Genotype may correlate with liver carcinogenesis and tumor characteristics in cirrhotic patients infected with hepatitis B virus subtype adw,” Journal of Medical Virology, vol. 65, no. 2, pp. 257–265, 2001. View at Publisher · View at Google Scholar · View at Scopus
  11. R. N. Chien, C. T. Yeh, S. L. Tsai, C. M. Chu, and Y. F. Liaw, “Determinants for sustained HBeAg response to lamivudine therapy,” Hepatology, vol. 38, no. 5, pp. 1267–1273, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. H. L. Y. Chan, A. Y. Hui, M. L. Wong et al., “Genotype C hepatitis B virus infection is associated with an increased risk of hepatocellular carcinoma,” Gut, vol. 53, no. 10, pp. 1494–1498, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. M. W. Yu, S. H. Yeh, P. J. Chen et al., “Hepatitis B virus genotype and DNA level and hepatocellular carcinoma: a prospective study in men,” Journal of the National Cancer Institute, vol. 97, no. 4, pp. 265–272, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. J. M. Sánchez-Tapias, J. Costa, A. Mas, M. Bruguera, and J. Rodés, “Influence of hepatitis B virus genotype on the long-term outcome of chronic hepatitis B in western patients,” Gastroenterology, vol. 123, no. 6, pp. 1848–1856, 2002. View at Publisher · View at Google Scholar · View at Scopus
  15. S. E. Livingston, J. P. Simonetti, B. J. McMahon et al., “Hepatitis B virus genotypes in Alaska Native people with hepatocellular carcinoma: preponderance of genotype F,” Journal of Infectious Diseases, vol. 195, no. 1, pp. 5–11, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. J. H. Kao, N. H. Wu, P. J. Chen, M. Y. Lai, and D. S. Chen, “Hepatitis B genotypes and the response to interferon therapy,” Journal of Hepatology, vol. 33, no. 6, pp. 998–1002, 2000. View at Publisher · View at Google Scholar · View at Scopus
  17. F. Tacke, C. Gehrke, T. Luedde, A. Heim, M. P. Manns, and C. Trautwein, “Basal core promoter and precore mutations in the hepatitis B virus genome enhance replication efficacy of lamivudine-resistant mutants,” Journal of Virology, vol. 78, no. 16, pp. 8524–8535, 2004. View at Publisher · View at Google Scholar · View at Scopus
  18. M. J. Tong, L. M. Blatt, J. H. Kao, J. T. Cheng, and W. G. Corey, “Basal core promoter T1762/A1764 and precore A1896 gene mutations in hepatitis B surface antigen-positive hepatocellular carcinoma: a comparison with chronic carriers,” Liver International, vol. 27, no. 10, pp. 1356–1363, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. Y. Wang, L. Wei, D. Jiang et al., “In vitro resistance to interferon-alpha of hepatitis B virus with basic core promoter double mutation,” Antiviral Research, vol. 75, no. 2, pp. 139–145, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. F. Cortés-Mancera and M. C. Navas, “Antiviral treatment response and clinical outcome of Hepatitis B virus infection: impact of genotype and precore/core variants,” Infection, vol. 3, pp. 201–216, 2008. View at Google Scholar
  21. M. Devesa, C. L. Loureiro, Y. Rivas et al., “Subgenotype diversity of hepatitis B Virus American Genotype F in Amerindians from Venezuela and the general population of Colombia,” Journal of Medical Virology, vol. 80, no. 1, pp. 20–26, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. M. V. Alvarado Mora, C. M. Romano, M. S. Gomes-Gouvêa et al., “Molecular characterization of the Hepatitis B virus genotypes in Colombia: a Bayesian inference on the genotype F,” Infection, Genetics and Evolution, vol. 11, no. 1, pp. 103–108, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. G. B. Zeng, S. J. Wen, Z. H. Wang, L. Yan, J. Sun, and J. L. Hou, “A novel hepatitis B virus genotyping system by using restriction fragment length polymorphism patterns of S gene amplicons,” World Journal of Gastroenterology, vol. 10, no. 21, pp. 3132–3136, 2004. View at Google Scholar · View at Scopus
  24. S. W. Chan, F. McOmish, E. C. Holmes et al., “Analysis of a new hepatitis C virus type and its phylogenetic relationship to existing variants,” Journal of General Virology, vol. 73, no. 5, pp. 1131–1141, 1992. View at Google Scholar · View at Scopus
  25. F. M. Cortés-Mancera, J. C. Restrepo, G. Osorio, S. Hoyos, G. Correa, and M. C. Navas, “Occult hepatitis C virus infection in a re-transplanted patient with liver failure of unknown etiology,” Revista Colombiana de Gastroenterologia, vol. 25, no. 1, pp. 76–85, 2010. View at Google Scholar · View at Scopus
  26. S. Gunther, B. C. Li, S. Miska, D. H. Kruger, H. Meisel, and H. Will, “A novel method for efficient amplification of whole hepatitis B virus genomes permits rapid functional analysis and reveals deletion mutants in immunosuppressed patients,” Journal of Virology, vol. 69, no. 9, pp. 5437–5444, 1995. View at Google Scholar · View at Scopus
  27. X. Hu, H. S. Margolis, R. H. Purcell, J. Ebert, and B. H. Robertson, “Identification of hepatitis B virus indigenous to chimpanzees,” Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 4, pp. 1661–1664, 2000. View at Publisher · View at Google Scholar · View at Scopus
  28. S. Schaefer, D. Glebe, U. C. Wend, J. Oyunbileg, and W. H. Gerlich, “Universal primers for real-time amplification of DNA from all known Orthohepadnavirus species,” Journal of Clinical Virology, vol. 27, no. 1, pp. 30–37, 2003. View at Publisher · View at Google Scholar · View at Scopus
  29. H. Norder, A. M. Couroucé, and L. O. Magnius, “Complete nucleotide sequences of six hepatitis B viral genomes encoding the surface antigen subtypes ayw4, adw4q-, and adrq- and their phylogenetic classification,” Archives of Virology, vol. 8, pp. 189–199, 1993. View at Google Scholar · View at Scopus
  30. J. M. Llovet and M. Beaugrand, “Hepatocellular carcinoma: present status and future prospects,” Journal of Hepatology, vol. 38, no. 1, pp. S136–S149, 2003. View at Google Scholar · View at Scopus
  31. D. Schuppan and N. H. Afdhal, “Liver cirrhosis,” The Lancet, vol. 371, no. 9615, pp. 838–851, 2008. View at Publisher · View at Google Scholar · View at Scopus
  32. F. de la Hoz, L. Perez, M. de Neira, and A. J. Hall, “Eight years of hepatitis B vaccination in Colombia with a recombinant vaccine: factors influencing hepatitis B virus infection and effectiveness,” International Journal of Infectious Diseases, vol. 12, no. 2, pp. 183–189, 2008. View at Publisher · View at Google Scholar · View at Scopus
  33. World Health Organization, “Hepatitis C-Global prevalence (update),” Weekly Epidemiological Record, vol. 75, pp. 18–19, 2000. View at Google Scholar
  34. M. Beltrán, M. Ayala, and R. Ching, “Situación actual del tamizaje en bancos de sangre,” Biomédica, vol. 16, no. 2, pp. 51–56, 1997. View at Google Scholar
  35. M. Beltrán, J. Raad, M. Ayala, and R. Ching, “Tamizaje de enfermedades infecciosas en bancos de sangre. Colombia, 1995,” Biomédica, vol. 17, no. 2, pp. 137–142, 1997. View at Google Scholar
  36. B. A. Cortés, M. Beltrán, B. Olaya, and M. Hernández, “Riesgo de enfermedades infecciosas transmitidas por transfusión en el Valle del Cauca, Colombia,” Colombia Medica, vol. 30, no. 1, pp. 13–18, 1999. View at Google Scholar · View at Scopus
  37. G. Muñoz, M. Velasco, V. Thiers et al., “Prevalence and genotypes of hepatitis C virus in blood donors and in patients with chronic liver disease and hepatocarcinoma in a Chilean population,” Revista médica de Chile, vol. 126, no. 9, pp. 1035–1042, 1998. View at Google Scholar
  38. A. Soza R and M. López-Lastra, “Hepatitis C in Chile: burden of the disease,” Revista Medica de Chile, vol. 134, no. 6, pp. 777–788, 2006. View at Google Scholar · View at Scopus
  39. E. Fassio, S. Díaz, C. Santa et al., “Etiology of hepatocellular carcinoma in Latin America: a prospective, multicenter, international study,” Annals of Hepatology, vol. 9, no. 1, pp. 63–69, 2010. View at Google Scholar · View at Scopus
  40. N. Méndez-Sánchez, J. R. Aguilar-Ramírez, A. Reyes et al., “Etiology of liver cirrhosis in Mexico,” Ann Hepatol, vol. 3, no. 1, pp. 30–33, 2004. View at Google Scholar · View at Scopus
  41. J. Cristina, “Genetic diversity and evolution of hepatitis C virus in the Latin American region,” Journal of Clinical Virology, vol. 34, no. 2, pp. S1–S7, 2005. View at Publisher · View at Google Scholar · View at Scopus
  42. R. C. Botero, E. Rojas, V. Idrovo, E. Ponce, and F. Sierra, “Genotipos del virus de la Hepatitis C (HCV) en Santa Fé de Bogotá,” Revista Colombiana de Gastroenterología, vol. 12, pp. 15–20, 1997. View at Google Scholar
  43. C. Santamaría, E. de Lima, and J. Holguín, “Hallazgos histológicos en infección crónica por el virus de la hepatitis C y su correlación con el genotipo viral, en Cali,” Colombia Medica, vol. 29, no. 1, pp. 20–23, 1998. View at Google Scholar · View at Scopus
  44. A. Yepes, C. Alvarez, J. C. Restrepo, G. Correa, J. C. Zapata, and A. E. Arango, “Viral genotypes in patients with hepatitis C virus infection in Medellín,” Gastroenterologia y Hepatologia, vol. 25, no. 5, pp. 334–335, 2002. View at Google Scholar · View at Scopus
  45. M. V. Mora, C. M. Romano, M. S. Gomes-Gouvêa, M. F. Gutiérrez, F. J. Carrilho, and J. R. Pinho, “Molecular characterization, distribution, and dynamics of hepatitis C virus genotypes in blood donors in Colombia,” Journal of Medical Virology, vol. 82, no. 11, pp. 1889–1898, 2010. View at Google Scholar
  46. S. A. Raza, G. M. Clifford, and S. Franceschi, “Worldwide variation in the relative importance of hepatitis B and hepatitis C viruses in hepatocellular carcinoma: a systematic review,” British Journal of Cancer, vol. 96, no. 7, pp. 1127–1134, 2007. View at Publisher · View at Google Scholar · View at Scopus
  47. S. Bruno, A. Crosignani, P. Maisonneuve, S. Rossi, E. Silini, and M. U. Mondelli, “Hepatitis C virus genotype 1b as a major risk factor associated with hepatocellular carcinoma in patients with cirrhosis: a seventeen-year prospective cohort study,” Hepatology, vol. 46, no. 5, pp. 1350–1356, 2007. View at Publisher · View at Google Scholar · View at Scopus
  48. S. Raimondi, S. Bruno, M. U. Mondelli, and P. Maisonneuve, “Hepatitis C virus genotype 1b as a risk factor for hepatocellular carcinoma development: a meta-analysis,” Journal of Hepatology, vol. 50, no. 6, pp. 1142–1154, 2009. View at Publisher · View at Google Scholar · View at Scopus
  49. Sivigila, “Sistema de Vigilancia en Salud Pública,” Informe Quincenal Epidemiológico Nacional, vol. 11, pp. 49–64, 2006. View at Google Scholar
  50. Sivigila, “Sistema de Vigilancia en Salud Pública,” Informe Quincenal Epidemiológico Nacional, vol. 11, pp. 279–312, 2006. View at Google Scholar
  51. N. M. Forones, L. A. Queiroz, V. F. Blum et al., “Hepatocarcinoma: analysis of 14 cases,” Revista da Associacao Medica Brasileira, vol. 40, no. 4, pp. 300–302, 1994. View at Google Scholar · View at Scopus
  52. C. S. Gonçalves, F. E. L. Pereira, and L. C. C. Gayotto, “Hepatocellular carcinoma in Brazil: report of a national survey (Florianópolis, SC, 1995),” Revista do Instituto de Medicina Tropical de Sao Paulo, vol. 39, no. 3, pp. 165–170, 1997. View at Google Scholar · View at Scopus
  53. E. C. Branco Mello Miranda, L. D. J. Pereira Mioa, I. D. S. Abraçado Amaral et al., “Hepatitis B and C virus infection and the hepatocellular carcinoma in the East Amazon, Brazil,” Revista da Sociedade Brasileira de Medicina Tropical, vol. 37, no. 2, pp. 47–51, 2004. View at Google Scholar · View at Scopus
  54. G. C. Leão-Filho, E. P. A. Lopes, A. A. Ferrazaz et al., “Hepatitis G virus infection in patients with hepatocellular carcinoma in Recife, Brazil,” Japanese Journal of Clinical Oncology, vol. 37, no. 8, pp. 632–636, 2007. View at Publisher · View at Google Scholar · View at Scopus
  55. E. Ruiz, M. Almonte, R. Pizarro, J. Celis, J. A. Montalbelti, and R. Urbano, “Hepatitis B and C virus infection as risk factors for Hepatocarcinoma in Peru: case and control study,” Revista de Gastroenterología del Perú, vol. 18, pp. 199–212, 1998. View at Google Scholar
  56. E. Ruiz, J. Sanchez, J. Celis et al., “Short and long-term results of liver resection for hepatocarcinoma in Peru: a Peruvian single center experience on 232 cases,” Revista de Gastroenterología del Perú, vol. 27, no. 3, pp. 223–237, 2007. View at Google Scholar · View at Scopus
  57. C. Manterola, S. Muñoz, J. C. Araya, C. Calderón, and M. S. Barroso, “Carcinoma hepatocellular. Description of verified clinical characteristics in a region of Southern Chile,” Revista médica de Chile, vol. 128, pp. 887–895, 2000. View at Google Scholar
  58. L. J. López-García, D. H. Toro, H. Mayol, J. Martínez-Souss, M. I. Dueño, and F. Rodríguez-Pérez, “Hepatocellular carcinoma: ten years experience among veterans in Puerto Rico,” Puerto Rico Health Sciences Journal, vol. 26, no. 2, pp. 103–107, 2007. View at Google Scholar · View at Scopus
  59. A. R. Jaysoom, P. O. Vicente, G. V. Cristina, C. Andra, C. M. Luis, and S. F. Roque, “Etiology, survival, complications and mortality in liver cirrhosis in Ecuador, 15 years retrospective evaluation (1989–2003),” Gastroenterol Latinoam, vol. 17, no. 1, pp. 29–34, 2006. View at Google Scholar
  60. M. Devesa and F. H. Pujol, “Hepatitis B virus genetic diversity in Latin America,” Virus Research, vol. 127, no. 2, pp. 177–184, 2007. View at Publisher · View at Google Scholar · View at Scopus
  61. L. G. Carvajal-Carmona, I. D. Soto, N. Pineda et al., “Strong Amerind/white sex bias and a possible Sephardic contribution among the founders of a population in Northwest Colombia,” American Journal of Human Genetics, vol. 67, no. 5, pp. 1287–1295, 2000. View at Google Scholar · View at Scopus
  62. G. Bedoya, P. Montoya, J. García et al., “Admixture dynamics in Hispanics: a shift in the nuclear genetic ancestry of a South American population isolate,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 19, pp. 7234–7239, 2006. View at Publisher · View at Google Scholar · View at Scopus
  63. M. V. Alvarado Mora, C. M. Romano, M. S. Gomes-Gouvêa, M. F. Gutierrez, F. J. Carrilho, and J. R.R. Pinho, “Molecular epidemiology and genetic diversity of hepatitis B virus genotype E in an isolated Afro-Colombian community,” Journal of General Virology, vol. 91, no. 2, pp. 501–508, 2010. View at Publisher · View at Google Scholar
  64. F. Cuellar-Ambrosi, M. C. Mondragon, M. Figueroa, C. Prehu, F. Galacteros, and A. Ruiz-Linares, “Sickle cell anemia and β-globin gene cluster haplotypes in Colombia,” Hemoglobin, vol. 24, no. 3, pp. 221–225, 2000. View at Google Scholar · View at Scopus
  65. T. T. T. Huy, H. Ushijima, T. Sata, and K. Abe, “Genomic characterization of HBV genotype F in Bolivia: genotype F subgenotypes correlate with geographic distribution and T1858 variant,” Archives of Virology, vol. 151, no. 3, pp. 589–597, 2006. View at Publisher · View at Google Scholar · View at Scopus
  66. C. M. Chu, C. T. Yeh, C. S. Lee, I. S. Sheen, and Y. F. Liaw, “Precore stop mutant in HBeAg-positive patients with chronic hepatitis B: clinical characteristics and correlation with the course of HBeAg-to-anti-HBe seroconversion,” Journal of Clinical Microbiology, vol. 40, no. 1, pp. 16–21, 2002. View at Publisher · View at Google Scholar · View at Scopus
  67. A. S. F. Lok, U. Akarca, and S. Greene, “Mutations in the pre-core region of hepatitis B virus serve to enhance the stability of the secondary structure of the pre-genome encapsidation signal,” Proceedings of the National Academy of Sciences of the United States of America, vol. 91, no. 9, pp. 4077–4081, 1994. View at Google Scholar · View at Scopus
  68. L. de Castro, C. Niel, and S. A. Gomes, “Low frequency of mutations in the core promoter and precore regions of hepatitis B virus in anti-HBe positive Brazilian carriers,” BMC Microbiology, vol. 1, p. 10, 2001. View at Google Scholar · View at Scopus
  69. R. Sitnik, J. R. R. Pinho, D. A. Bertolini, A. P. Bernardini, L. C. da Silva, and F. J. Carrilho, “Hepatitis B virus genotypes and precore and core mutants in Brazilian patients,” Journal of Clinical Microbiology, vol. 42, no. 6, pp. 2455–2460, 2004. View at Publisher · View at Google Scholar · View at Scopus
  70. J. Li, V. E. Buckwold, M. W. Hon, and J. H. Ou, “Mechanism of suppression of hepatitis B virus precore RNA transcription by a frequent double mutation,” Journal of Virology, vol. 73, no. 2, pp. 1239–1244, 1999. View at Google Scholar · View at Scopus
  71. J. H. Kao, P. J. Chen, M. Y. Lai, and D. S. Chen, “Basal core promoter mutations of hepatitis B virus increase the risk of hepatocellular carcinoma in hepatitis B carriers,” Gastroenterology, vol. 124, no. 2, pp. 327–334, 2003. View at Publisher · View at Google Scholar · View at Scopus
  72. A. Kramvis, K. Arakawa, M. C. Yu, R. Nogueira, D. O. Stram, and M. C. Kew, “Relationship of serological subtype, basic core promoter and precore mutations to genotypes/subgenotypes of hepatitis B virus,” Journal of Medical Virology, vol. 80, no. 1, pp. 27–46, 2008. View at Publisher · View at Google Scholar · View at Scopus