Table of Contents
Hepatitis Research and Treatment
Volume 2011, Article ID 367908, 8 pages
http://dx.doi.org/10.1155/2011/367908
Review Article

Effects of HBV Genetic Variability on RNAi Strategies

1Department of Biochemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand
2Department of Biochemistry, University of Otago, Dunedin 9016, New Zealand

Received 31 January 2011; Accepted 15 April 2011

Academic Editor: Patrick Soussan

Copyright © 2011 Nattanan Panjaworayan and Chris M. Brown. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

RNAi strategies present promising antiviral strategies against HBV. RNAi strategies require base pairing between short RNAi effectors and targets in the HBV pregenome or other RNAs. Natural variation in HBV genotypes, quasispecies variation, or mutations selected by the RNAi strategy could potentially make these strategies less effective. However, current and proposed antiviral strategies against HBV are being, or could be, designed to avoid this. This would involve simultaneous targeting of multiple regions of the genome, or regions in which variation or mutation is not tolerated. RNAi strategies against single genotypes or against variable regions of the genome would need to have significant other advantages to be part of robust therapies.