Table of Contents
Hepatitis Research and Treatment
Volume 2011 (2011), Article ID 475965, 6 pages
http://dx.doi.org/10.1155/2011/475965
Research Article

TP53 Mutations and HBX Status Analysis in Hepatocellular Carcinomas from Iran: Evidence for Lack of Association between HBV Genotype D and TP53 R249S Mutations

1Mechanisms of Carcinogenesis Section, Molecular Carcinogenesis Group, International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372 Lyon, France
2Digestive Disease Research Center, Shariati Hospital, Tehran University of Medical Sciences, Kargar Shomali Avenue, 14117 Tehran, Iran

Received 4 May 2011; Accepted 18 June 2011

Academic Editor: Isabelle Chemin

Copyright © 2011 Behnoush Abedi-Ardekani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Ferlay, H. R. Shin, F. Bray, D. Forman, C. Mathers, and D. M. Parkin, “Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008,” International Journal of Cancer, vol. 127, no. 12, pp. 2893–2917, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. J. D. Yang and L. R. Roberts, “Hepatocellular carcinoma: a global view,” Nature Reviews Gastroenterology and Hepatology, vol. 7, no. 8, pp. 448–458, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. X. H. Liu, J. Lin, S. H. Zhang et al., “COOH-terminal deletion of HBx gene is a frequent event in HBV-associated hepatocellular carcinoma,” World Journal of Gastroenterology, vol. 14, no. 9, pp. 1346–1352, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. R. A. Lizzano, B. Yang, A. J. Clippinger, and M. J. Bouchard, “The C-terminal region of the hepatitis B virus X protein is essential for its stability and function,” Virus Research, vol. 155, no. 1, pp. 231–239, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. N. F. Ma, S. H. Lau, L. Hu et al., “COOH-terminal truncated HBV X protein plays key role in hepatocarcinogenesis,” Clinical Cancer Research, vol. 14, no. 16, pp. 5061–5068, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. C. Neuveut, Y. Wei, and M. A. Buendia, “Mechanisms of HBV-related hepatocarcinogenesis,” Journal of Hepatology, vol. 52, no. 4, pp. 594–604, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. H. L. Chan, “JGH foundation emerging leadership lecture. Significance of hepatitis B virus genotypes and mutations in the development of hepatocellular carcinoma in Asia,” Journal of Gastroenterology and Hepatology, vol. 26, no. 1, pp. 8–12, 2011. View at Google Scholar
  8. P. Vivekanandan, M. Torbenson, and B. Ramakrishna, “Hepatitis B virus-associated hepatocellular carcinoma from India: role of viral genotype and mutations in CTNNB1 (beta-catenin) and TP53 genes,” Journal of Gastrointestinal Cancer, vol. 24, no. 1, pp. 20–25, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. J. Yin, H. Zhang, Y. He et al., “Distribution and hepatocellular carcinoma-related viral properties of hepatitis B virus genotypes in Mainland China: a community-based study,” Cancer Epidemiology Biomarkers and Prevention, vol. 19, no. 3, pp. 777–786, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. W. Jiang, X. W. Wang, T. Unger et al., “Cooperation of tumor-derived HBx mutants and p53-249ser mutant in regulating cell proliferation, anchorage-independent growth and aneuploidy in a telomerase-immortalized normal human hepatocyte-derived cell line,” International Journal of Cancer, vol. 127, no. 5, pp. 1011–1020, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. D. Gouas, H. Shi, and P. Hainaut, “The aflatoxin-induced TP53 mutation at codon 249 (R249S): biomarker of exposure, early detection and target for therapy,” Cancer Letters, vol. 286, no. 1, pp. 29–37, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. Q. Dong, H. L. Y. Chan, Z. Liu et al., “A1762T/G1764A mutations of hepatitis B virus, associated with the increased risk of hepatocellular carcinoma, reduce basal core promoter activities,” Biochemical and Biophysical Research Communications, vol. 374, no. 4, pp. 773–776, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. S. Y. Kuang, S. Lekawanvijit, N. Maneekarn et al., “Hepatitis B 1762T/1764A mutations, hepatitis C infection, and codon 249 p53 mutations in hepatocellular carcinomas from Thailand,” Cancer Epidemiology Biomarkers and Prevention, vol. 14, no. 2, pp. 380–384, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. M. E. Mendy, S. Kaye, R. E. Le et al., “Application of a novel, rapid, and sensitive oligonucleotide ligation assay for detection of cancer-predicting mutations in the precore and basal core promoter of hepatitis B virus,” Journal of Clinical Microbiology, vol. 46, no. 8, pp. 2723–2730, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. J. M. Yuan, A. Ambinder, Y. Fan, Y. T. Gao, M. C. Yu, and J. D. Groopman, “Prospective evaluation of hepatitis B 1762(T)/1764(A) mutations on hepatocellular carcinoma development in Shanghai, China,” Cancer Epidemiology Biomarkers and Prevention, vol. 18, no. 2, pp. 590–594, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. S. Merat, H. Rezvan, M. Nouraie et al., “The prevalence of hepatitis B surface antigen and anti-hepatitis B core antibody in Iran: a population-based study,” Archives of Iranian Medicine, vol. 12, no. 3, pp. 225–231, 2009. View at Google Scholar · View at Scopus
  17. A. Aghakhani, R. Hamkar, N. Zamani et al., “Hepatitis B virus genotype in Iranian patients with hepatocellular carcinoma,” International Journal of Infectious Diseases, vol. 13, no. 6, pp. 685–689, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Mojiri, A. Behzad-Behbahani, M. Saberifirozi et al., “Hepatitis B virus genotypes in southwest Iran: molecular, serological and clinical outcomes,” World Journal of Gastroenterology, vol. 14, no. 10, pp. 1510–1513, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. A. M. Cheraghali, H. Yazdanpanah, N. Doraki et al., “Incidence of aflatoxins in Iran pistachio nuts,” Food and Chemical Toxicology, vol. 45, no. 5, pp. 812–816, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. S. A. Ghiasian, G. S. Shephard, and H. Yazdanpanah, “Natural occurrence of aflatoxins from maize in Iran,” Mycopathologia, vol. 172, no. 2, pp. 153–160, 2011. View at Google Scholar
  21. M. Mazaheri, “Determination of aflatoxins in imported rice to Iran,” Food and Chemical Toxicology, vol. 47, no. 8, pp. 2064–2066, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. G. D. Kirk, O. A. Lesi, M. Mendy et al., “249(ser) TP53 mutation in plasma DNA, hepatitis B viral infection, and risk of hepatocellular carcinoma,” Oncogene, vol. 24, no. 38, pp. 5858–5867, 2005. View at Publisher · View at Google Scholar · View at Scopus
  23. K. Tamura, D. Peterson, N. Peterson, G. Stecher, M. Nei, and S. Kumar, “MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum Parsimony methods,” Molecular Biology and Evolution. In press. View at Publisher · View at Google Scholar
  24. K. Kidd-Ljunggren, Y. Miyakawa, and A. H. Kidd, “Genetic variability in hepatitis B viruses,” Journal of General Virology, vol. 83, no. 6, pp. 1267–1280, 2002. View at Google Scholar · View at Scopus
  25. G. D. Kirk, O. A. Lesi, M. Mendy et al., “The Gambia liver cancer study: infection with hepatitis B and C and the risk of hepatocellular carcinoma in West Africa,” Hepatology, vol. 39, no. 1, pp. 211–219, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. M. E. Lleonart, G. D. Kirk, S. Villar et al., “Quantitative analysis of plasma TP53 249Ser-mutated DNA by electrospray ionization mass spectrometry,” Cancer Epidemiology Biomarkers and Prevention, vol. 14, no. 12, pp. 2956–2962, 2005. View at Publisher · View at Google Scholar · View at Scopus