Table of Contents
Hepatitis Research and Treatment
Volume 2011 (2011), Article ID 582945, 10 pages
http://dx.doi.org/10.1155/2011/582945
Research Article

Hepatitis B and Hepatitis C Infection Biomarkers and TP53 Mutations in Hepatocellular Carcinomas from Colombia

1Grupo de Gastrohepatologia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia
2International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372 Lyon, France
3Departamento de Patología, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia
4Hospital Pablo Tobón Uribe, Medellín, Colombia
5Departamento de Patologia, Fundacion Santa Fe de Bogota, Bogotá D.C., Colombia
6Departamento de Patología, Facultad de Salud, Universidad del Valle, Cali, Colombia
7Grupo de Epidemiologia, Facultad Nacional de Salud Publica, Universidad de Antioquia, Medellín, Colombia
8Service d’Anatomie Pathologique, Hôpital Edouard Herriot, 69437 Lyon, France
9Mailman School of Public Health, Columbia University, NY 10032, USA
10INSERM U871, 69424 Lyon, France

Received 23 March 2011; Accepted 22 August 2011

Academic Editor: Patrick Soussan

Copyright © 2011 Maria-Cristina Navas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Hepatocellular Carcinoma (HCC) is a leading cause of cancer-related death worldwide. Globally, the most important HCC risk factors are Hepatitis B Virus (HBV) and/or Hepatitis C Virus (HCV), chronic alcoholism, and dietary exposure to aflatoxins. We have described the epidemiological pattern of 202 HCC samples obtained from Colombian patients. Additionally we investigated HBV/HCV infections and TP53 mutations in 49 of these HCC cases. HBV biomarkers were detected in 58.1% of the cases; HBV genotypes F and D were characterized in three of the samples. The HCV biomarker was detected in 37% of the samples while HBV/HCV coinfection was found in 19.2%. Among TP53 mutations, 10.5% occur at the common aflatoxin mutation hotspot, codon 249. No data regarding chronic alcoholism was available from the cases. In conclusion, in this first study of HCC and biomarkers in a Colombian population, the main HCC risk factor was HBV infection.