Table of Contents
Hepatitis Research and Treatment
Volume 2011, Article ID 582945, 10 pages
http://dx.doi.org/10.1155/2011/582945
Research Article

Hepatitis B and Hepatitis C Infection Biomarkers and TP53 Mutations in Hepatocellular Carcinomas from Colombia

1Grupo de Gastrohepatologia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia
2International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372 Lyon, France
3Departamento de Patología, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia
4Hospital Pablo Tobón Uribe, Medellín, Colombia
5Departamento de Patologia, Fundacion Santa Fe de Bogota, Bogotá D.C., Colombia
6Departamento de Patología, Facultad de Salud, Universidad del Valle, Cali, Colombia
7Grupo de Epidemiologia, Facultad Nacional de Salud Publica, Universidad de Antioquia, Medellín, Colombia
8Service d’Anatomie Pathologique, Hôpital Edouard Herriot, 69437 Lyon, France
9Mailman School of Public Health, Columbia University, NY 10032, USA
10INSERM U871, 69424 Lyon, France

Received 23 March 2011; Accepted 22 August 2011

Academic Editor: Patrick Soussan

Copyright © 2011 Maria-Cristina Navas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. Peter and B. Levin, Eds., World Cancer Report 2008, International Agency for Research on Cancer, 2008.
  2. J. F. Perz, G. L. Armstrong, L. A. Farrington, Y. J. Hutin, and B. P. Bell, “The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide,” Journal of Hepatology, vol. 45, no. 4, pp. 529–538, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. A. P. Venook, C. Papandreou, J. Furuse, and L. L. de Guevara, “The incidence and epidemiology of hepatocellular carcinoma: a global and regional perspective,” The Oncologist, vol. 15, supplement 4, pp. 5–13, 2010. View at Google Scholar
  4. International Agency for Research on Cancer, Cancer Incidence in Five Continents, vol. 9, 2007.
  5. COLOMBIA. DANE (Departamento Administrativo Nacional de Estadística). Dirección de Censos y Demografía. Bogota, 2001.
  6. E. Fassio, S. Díaz, C. Santa et al., “Etiology of hepatocellular carcinoma in Latin America: a prospective, multicenter, international study,” Annals of Hepatology, vol. 9, no. 1, pp. 63–69, 2010. View at Google Scholar · View at Scopus
  7. M. S. Añez, P. Zabaleta, L. Umbria et al., “Carcinoma hepatocellular en los Andes Venezolanos,” GEN, vol. 40, no. 2, pp. 66–70, 1986. View at Google Scholar · View at Scopus
  8. R. Mondragón, F. Ochoa, J. Ruiz, R. H. Goepfer, L. F.O. Ocana, and V. A. Crocifoglio, “Carcinoma hepatocelular. Experiencia en el Instituto Nacional de Cancerología,” Revista de Gastroenterologia, vol. 62, no. 1, pp. 34–40, 1997. View at Google Scholar
  9. J. O. Curciarello, L. D. Vélez, J. D. Bosia et al., “Carcinoma hepatocelular: características clinicoepidemiológicas,” Acta Gastroenterologica Latinoamericana, vol. 28, no. 3, pp. 243–247, 1998. View at Google Scholar · View at Scopus
  10. H. R. Bueno, S. Indacochea, R. B. Oberst, and G. Chauca, “Rol de los virus de la hepatitis B and Delta en la etiología del hepatocarcinoma y otras crónicas,” Revista de Gastroenterologia del Peru, vol. 14, no. 2, pp. 135–139, 1994. View at Google Scholar · View at Scopus
  11. A. A. Mattos, S. B. Machado, M. L. Lucas, and C. G. Zettler, “Expresao da proteína mutente do gene supressor tumoral p53 em carcinoma hepatocelular no Sul do brasil: estudo imuno-histoquimico,” Gastroenterologia Endoscopia Digestive, vol. 18, pp. 197–203, 1999. View at Google Scholar
  12. C. S. Gonçalves, F. E. Pereira, and L. C. Gayotto, “Hepatocellular carcinoma in Brazil: report of a national survey (Florianópolis, SC, 1995),” Revista do Instituto de Medicina Tropical de Sao Paulo, vol. 39, no. 3, pp. 165–170, 1997. View at Google Scholar · View at Scopus
  13. E. Fassio, C. Míguez, S. Soria et al., “Etiology of hepatocellular carcinoma in Argentina: results of a multicenter retrospective study,” Acta Gastroenterologica Latinoamericana, vol. 39, no. 1, pp. 47–52, 2009. View at Google Scholar · View at Scopus
  14. M. Gabrielli, M. Vivanco, J. Hepp et al., “Liver transplantation results for hepatocellular carcinoma in Chile,” Transplantation Proceedings, vol. 42, no. 1, pp. 299–301, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. F. de la Hoz, L. Perez, J. G. Wheeler, M. de Neira, and A. J. Hall, “Vaccine coverage with hepatitis B and other vaccines in the Colombian Amazon: do health worker knowledge and perception influence coverage?” Tropical Medicine and International Health, vol. 10, no. 4, pp. 322–329, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. F. de la Hoz, L. Perez, M. de Neira, and A. J. Hall, “Eight years of hepatitis B vaccination in Colombia with a recombinant vaccine: factors influencing hepatitis B virus infection and effectiveness,” International Journal of Infectious Diseases, vol. 12, no. 2, pp. 183–189, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. M. Beltrân, M. C. Navas, F. de la Hoz et al., “Hepatitis C virus seroprevalence in multi-transfused patients in Colombia,” Journal of Clinical Virology, vol. 34, supplement 2, pp. S33–S38, 2005. View at Publisher · View at Google Scholar · View at Scopus
  18. S. Duarte-Vogel and L. C. Villamil-Jiménez, “Micotoxinas en salud pública,” Revista de Salud Pública, vol. 8, supplement 1, pp. 129–135, 2006. View at Google Scholar · View at Scopus
  19. G. J. Diaz, N. S. Perilla, and Y. Rojas, “Ocurrence of aflatoxins in selected Colombian foods,” Mycotoxin Research, vol. 17, no. 1, pp. 15–20, 2001. View at Publisher · View at Google Scholar
  20. I. Gaviria and J. Giraldo, in Evaluación Genotóxica de Aflatoxinas Aisladas de Maíz Almacenado para Consumo Humano y Animal, Facultad de Ciencias Exactas y Naturales. Universidad de Antioquia, Antioquia, Colombia, 1995.
  21. M. Carpintero, N. Ruiz, and N. Peña, “Niveles de aflatoxina B1 en dos zonas del país. Primera cosecha de 1979,” Revista ICA, vol. 3, 1980. View at Google Scholar
  22. O. Cárdenas, “Contaminación de aflatoxinas en productos agrícolas nacionales. Sorgo del Meta,” Istituto Italiano di Tecnologia, vol. 161, no. 26, pp. 41–47, 1986. View at Google Scholar
  23. G. Prado, “Incidencia de aflatoxina B1 em alimentos,” Revista de Farmácia e Bioquímica, vol. 5, no. 2, pp. 147–157, 1983. View at Google Scholar
  24. L. L. Hsieh, S. W. Hsu, D. S. Chen, and R. M. Santella, “Immunological detection of aflatoxin B1-DNA adducts formed in vivo,” Cancer Research, vol. 48, no. 22, pp. 6328–6331, 1988. View at Google Scholar
  25. K. Szymánska, O. A. Lesi, G. D. Kirk et al., “Ser-249 TP53 mutation in tumour and plasma DNA of hepatocellular carcinoma patients from a high incidence area in the Gambia, West Africa,” International Journal of Cancer, vol. 110, no. 3, pp. 374–379, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. G. Hosny, N. Farahat, and P. Hainaut, “TP53 mutations in circulating free DNA from Egyptian patients with non-Hodgkin's lymphoma,” Cancer Letters, vol. 275, no. 2, pp. 234–239, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. G. B. Zeng, S. J. Wen, Z. H. Wang, L. Yan, J. Sun, and J. L. Hou, “A novel hepatitis B virus genotyping system by using restriction fragment length polymorphism patterns of S gene amplicons,” World Journal of Gastroenterology, vol. 10, no. 21, pp. 3132–3136, 2004. View at Google Scholar · View at Scopus
  28. S. Schaefer, D. Glebe, U. C. Wend, J. Oyunbileg, and W. H. Gerlich, “Universal primers for real-time amplification of DNA from all known orthohepadnavirus species,” Journal of Clinical Virology, vol. 27, no. 1, pp. 30–37, 2003. View at Publisher · View at Google Scholar · View at Scopus
  29. H. Norder, B. Hammas, S. D. Lee et al., “Genetic relatedness of hepatitis B viral strains of diverse geographical origin and natural variations in the primary structure of the surface antigen,” Journal of General Virology, vol. 74, no. 7, pp. 1341–1348, 1993. View at Google Scholar · View at Scopus
  30. N. Méndez-Sánchez, A. R. Villa, G. Vázquez-Elizondo, G. Ponciano-Rodríguez, and M. Uribe, “Mortality trends for liver cancer in Mexico from 2000 to 2006,” Annals of Hepatology, vol. 7, no. 3, pp. 226–229, 2008. View at Google Scholar · View at Scopus
  31. F. L. O. Jaramillo and L. P. M. Vélez, “Mortalidad por cáncer en Colombia 2001,” CES Medicina, vol. 18, no. 2, pp. 19–36, 2004. View at Google Scholar
  32. Dirección Seccional de Salud de Antioquia, “Registro poblacional de cáncer. Diez primeras causas de mortalidad por grupos de edad según 105 grupos,” Departamento de Antioquia 2005, http://www.dssa.gov.co/index.php/estadisticas/registro-poblacional-de-cancer.
  33. H. B. El-Serag and K. L. Rudolph, “Hepatocellular carcinoma: epidemiology and molecular carcinogenesis,” Gastroenterology, vol. 132, no. 7, pp. 2557–2576, 2007. View at Publisher · View at Google Scholar · View at Scopus
  34. C. B. Sánchez, J. D. Ferrer, R. R. Vargas, M. D. Moscol, and E. Z. Villena, “Clinical—epidemiological characteristics of the hepatocellular carcinoma and treatment in the departament of digestive system diseases of the National Hospital “Eduardo Rebagliatti Martins” (HNERM)—ESSALUD,” Revista de Gastroenterología del Perú, vol. 29, no. 1, pp. 17–23, 2009. View at Google Scholar · View at Scopus
  35. E. Ruiz, J. Sanchez, J. Celis et al., “Short and long-term results of liver resection for hepatocarcinoma in Peru: a Peruvian single center experience on 232 cases,” Revista de Gastroenterologia del Perú, vol. 27, no. 3, pp. 223–237, 2007. View at Google Scholar · View at Scopus
  36. A. Petitjean, E. Mathe, S. Kato et al., “Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database,” Human Mutation, vol. 28, no. 6, pp. 622–629, 2007. View at Publisher · View at Google Scholar · View at Scopus
  37. I. C. Hsu, R. A. Metcalf, T. Sun, J. A. Welsh, N. J. Wang, and C. C. Harris, “Mutational hotspot in the p53 gene in human hepatocellular carcinomas,” Nature, vol. 350, no. 6317, pp. 427–428, 1991. View at Publisher · View at Google Scholar · View at Scopus
  38. M. C. Stern, D. M. Umbach, M. C. Yu, S. J. London, Z. Q. Zhang, and J. A. Taylor, “Hepatitis B, aflatoxin B1, and p53 codon 249 mutation in hepatocellular carcinomas from Guangxi, People's Republic of China, and a Meta-analysis of existing studies,” Cancer Epidemiology Biomarkers and Prevention, vol. 10, no. 6, pp. 617–625, 2001. View at Google Scholar · View at Scopus
  39. G. D. Kirk, O. A. Lesi, M. Mendy et al., “249ser TP53 mutation in plasma DNA, hepatitis B viral infection, and risk of hepatocellular carcinoma,” Oncogene, vol. 24, no. 38, pp. 5858–5867, 2005. View at Publisher · View at Google Scholar · View at Scopus
  40. H. Liu, Y. Wang, Q. Zhou, S. Y. Gui, and X. Li, “The point mutation of p53 gene exon7 in hepatocellular carcinoma from Anhui province, a non HCC prevalent area in China,” World Journal of Gastroenterology, vol. 8, no. 3, pp. 480–482, 2002. View at Google Scholar · View at Scopus
  41. S. Katiyar, B. C. Dash, V. Thakur, R. C. Guptan, S. K. Sarin, and B. C. Das, “p53 tumor suppressor gene mutations in hepatocellular carcinoma patients in India,” Cancer, vol. 88, no. 7, pp. 1565–1573, 2000. View at Publisher · View at Google Scholar · View at Scopus
  42. R. M. Lunn, Y. J. Zhang, L. Y. Wang et al., “p53 mutations, chronic hepatitis B virus infection, and aflatoxin exposure in hepatocellular carcinoma in Taiwan,” Cancer Research, vol. 57, no. 16, pp. 3471–3477, 1997. View at Google Scholar · View at Scopus
  43. F. T. Özdemir, A. Tiftikci, S. Sancak et al., “The prevalence of the mutation in codon 249 of the P53 gene in patients with hepatocellular carcinoma (HCC) in Turkey,” Journal of Gastrointestinal Cancer, vol. 41, no. 3, pp. 185–189, 2010. View at Publisher · View at Google Scholar · View at Scopus
  44. Y. J. Zhang, P. Rossner Jr, Y. Chen et al., “Aflatoxin B1 and polycyclic aromatic hydrocarbon adducts, p53 mutations and p16 methylation in liver tissue and plasma of hepatocellular carcinoma patients,” International Journal of Cancer, vol. 119, no. 5, pp. 985–991, 2006. View at Publisher · View at Google Scholar · View at Scopus
  45. Y. Soini, S. C. Chia, W. P. Bennett et al., “An aflatoxin-associated mutational hotspot at codon 249 in the p53 tumor suppressor gene occurs in hepatocellular carcinomas from Mexico,” Carcinogenesis, vol. 17, no. 5, pp. 1007–1012, 1996. View at Publisher · View at Google Scholar · View at Scopus
  46. J. A. Nogueira, S. K. Ono-Nita, M. E. Nita et al., “249 TP53 mutation has high prevalence and is correlated with larger and poorly differentiated HCC in Brazilian patients,” BMC Cancer, vol. 9, no. 204, 2009. View at Publisher · View at Google Scholar · View at Scopus
  47. Sivigila, “Sistema de vigilancia en salud pública,” Inf Quinc Epidemiol Nac, vol. 11, pp. 49–64, 2006. View at Google Scholar
  48. Sivigila, “Sistema de vigilancia en salud pública,” Inf Quinc Epidemiol Nac, vol. 11, pp. 297–312, 2006. View at Google Scholar
  49. M. Devesa, C. L. Loureiro, Y. Rivas et al., “Subgenotype diversity of hepatitis B Virus American genotype F in amerindians from Venezuela and the general population of Colombia,” Journal of Medical Virology, vol. 80, no. 1, pp. 20–26, 2008. View at Publisher · View at Google Scholar · View at Scopus
  50. M. V. A. Mora, C. M. Romano, M. S. Gomes-Gouvêa et al., “Molecular characterization of the hepatitis B virus genotypes in Colombia: a bayesian inference on the genotype F,” Infection, Genetics and Evolution, vol. 11, no. 1, pp. 103–108, 2011. View at Publisher · View at Google Scholar · View at Scopus
  51. F. Cortes-Mancera, C. L. Loureiro, S. Hoyos et al., “Etiology and viral genotype in patients with end-stage liver diseases admitted to a Hepatology unit in Colombia,” Hepatitis Research and Treatment, vol. 2011, Article ID 363205, 10 pages, 2011. View at Publisher · View at Google Scholar
  52. M. V. A. Mora, C. M. Romano, M. S. Gomes-Gouvêa, M. F. Gutierrez, F. J. Carrilho, and J. R. R. Pinho, “Molecular epidemiology and genetic diversity of hepatitis B virus genotype E in an isolated Afro-Colombian community,” Journal of General Virology, vol. 91, no. 2, pp. 501–508, 2010. View at Publisher · View at Google Scholar · View at Scopus