Table of Contents
Hepatitis Research and Treatment
Volume 2011, Article ID 697162, 9 pages
http://dx.doi.org/10.1155/2011/697162
Research Article

Mutations in TP53 and CTNNB1 in Relation to Hepatitis B and C Infections in Hepatocellular Carcinomas from Thailand

1INSERM U1052, 151 Cours Albert Thomas, 69003 Lyon, France
2International Agency for Research on Cancer, 150 Cours Albert Thomas, Cedex 08, 69372 Lyon, France
3Departamento de Patología, Universidad de Antioquia, SIU, Carrera 51 no. 61-30, Medellín, Colombia
4Grupo de Gastrohepatología, Universidad de Antioquia, SIU, Carrera 51 no. 61-30, Medellín, Colombia
5Biomnis, Anatomie et Cytologie Pathologiques, 17/19 Avenue Tony Garnier, 69007 Lyon, France
6Department of Virology, Swedish Institute for Infectious Disease Control (Smittskyddsinstitutet, SMI), Solna, Sweden
7Cancer Control Unit, National Cancer Institute, 268/1 Rama VI Road, Bangkok 10400, Thailand
8Research Division, National Cancer Institute, Rama VI Road, Bangkok 10400, Thailand

Received 25 February 2011; Accepted 4 May 2011

Academic Editor: Patrick Soussan

Copyright © 2011 Olivier Galy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Hepatocellular carcinoma (HCC) may develop according to two major pathways, one involving HBV infection and TP53 mutation and the other characterized by HCV infection and CTNNB1 mutation. We have investigated HBV/HCV infections and TP53/CTNNB1 mutations in 26 HCC patients from Thailand. HBV DNA (genotype B or C) was detected in 19 (73%) of the cases, including 5 occult infections and 3 coinfections with HCV. TP53 and CTNNB1 mutations were not mutually exclusive, and most of TP53 mutations were R249S, suggesting a significant impact of aflatoxin-induced mutagenesis in HCC development.