Table of Contents
Hepatitis Research and Treatment
Volume 2011, Article ID 697162, 9 pages
Research Article

Mutations in TP53 and CTNNB1 in Relation to Hepatitis B and C Infections in Hepatocellular Carcinomas from Thailand

1INSERM U1052, 151 Cours Albert Thomas, 69003 Lyon, France
2International Agency for Research on Cancer, 150 Cours Albert Thomas, Cedex 08, 69372 Lyon, France
3Departamento de Patología, Universidad de Antioquia, SIU, Carrera 51 no. 61-30, Medellín, Colombia
4Grupo de Gastrohepatología, Universidad de Antioquia, SIU, Carrera 51 no. 61-30, Medellín, Colombia
5Biomnis, Anatomie et Cytologie Pathologiques, 17/19 Avenue Tony Garnier, 69007 Lyon, France
6Department of Virology, Swedish Institute for Infectious Disease Control (Smittskyddsinstitutet, SMI), Solna, Sweden
7Cancer Control Unit, National Cancer Institute, 268/1 Rama VI Road, Bangkok 10400, Thailand
8Research Division, National Cancer Institute, Rama VI Road, Bangkok 10400, Thailand

Received 25 February 2011; Accepted 4 May 2011

Academic Editor: Patrick Soussan

Copyright © 2011 Olivier Galy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Tabel S1: Sorting of the 26 HCC studied according to HBsAg status.

Tabel S2: DHPLC conditions for exon 3 of CTNNB1 gene.

Figure S3: Alignments of HBsAg in determinant “a” region from 11 HBV patients (classified as genotype C except samples marked with stars which are genotype B). Samples 10, 26 and 27 are occult HBV infections. R145G is a common mutation causing false negative results for HBV serological testing using first generation antibodies. Double mutant A126I / T127P was detected in case 26.

  1. Supplementary Material