Reexamining Povarov Reaction’s Scope and Limitation in the Generation of HCV-NS4A Peptidomimetics

Figure 1

Conserved conformation of NS4A peptide in bound form with NS3 protease domain. (a) Examples of bound NS4A downloaded from the PDB website (rcsb.org) and illustrated as follows: 1A1R (Green), 2OC1 (magenta), 3OYP (Red), and 4U01 (Blue). (b) The binding of NS4A (PDB Code: 1NS3) with apoprotein residues guided our peptidomimetics design. (c) Dihedral angles θ_n of the bound NS4A’s planar region (PDB Code: 1NS3). Numerical values of θ₁ to θ₅ are listed in Table 1.

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