Reexamining Povarov Reaction’s Scope and Limitation in the Generation of HCV-NS4A Peptidomimetics

<div>Stability study of <i>tert-</i>Butyl (5-(Pyridin-2-yl)-3,4,4<i>a</i>,5,6,10<i>b</i>-hexahydro-<i>2H</i>-pyrano[3,2-<i>c</i>] [1, 7]naphthyridin-9-yl)carbamate (5l), Entry 50. (a) Pure 1a right after HPLC purification. (b) LC/MS after 7 hours are showing complete decomposition of one isomer (Rt = 2.06) while the isomer at Rt = 2.16 min peak is detected. (c) LC/MS after 24 hours showed disappearance of both peaks of the compound.</div>

Heteroatom Chemistry

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Figure 3

Figure 3: Reexamining Povarov Reaction’s Scope and Limitation in the Generation of HCV-NS4A Peptidomimetics 