Reexamining Povarov Reaction’s Scope and Limitation in the Generation of HCV-NS4A Peptidomimetics

<div>Changes in the aggregation temperature (<i>T</i><sub>agg</sub>) in DSLS protein thermal stability assay (25-85°C). (a) Compound 4m mixed with NS3 (right plots) compared to NS3 alone (left plots). (b) Positive reference NS4A mixed with NS3 (right plots) compared to NS3 (left plots).</div>

Heteroatom Chemistry

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Figure 4

Figure 4: Reexamining Povarov Reaction’s Scope and Limitation in the Generation of HCV-NS4A Peptidomimetics 