Reexamining Povarov Reaction’s Scope and Limitation in the Generation of HCV-NS4A Peptidomimetics

Scheme 1

Putative Scheme for synthesis of scaffold 2 compounds. Cat = Lewis acid catalyst, THN = 1,2,3,4-tetrahydro-1,7-naphthyridine, THQ = 1,2,3,4-tetrahydroquinoline.