Reexamining Povarov Reaction’s Scope and Limitation in the Generation of HCV-NS4A Peptidomimetics

Scheme 4

Povarov reactions using mono-Boc-1,4-phenylenediamine (1b) and 5-amino-2-(N-Boc-amino)-pyridine (1c), aldehydes (2a-d & 2f-g), and alkenes (3a-c & 3f) using CAN or M-KSF as catalysts (Cat.).