Reexamining Povarov Reaction’s Scope and Limitation in the Generation of HCV-NS4A Peptidomimetics

Table 2

Results of Povarov reactions are shown in Scheme 2.

Entry	Product	Catalyst	Product %
1	4a	CAN	59%
2	4b	CAN	18%
3		M-KSF	62%
4	4c	CAN	80%,
5		M-KSF	68%
6	4d	CAN	50%
7		M-KSF	48%
8	4e	CAN	ND
9		M-KSF	ND, 43% of [M+H]^+ 202
10	4f	CAN	32% product and 15% of [M+H]^+ 202
11		M-KSF	22% product and 30% of [M+H]^+ 202
12	4g	CAN	80%
13		M-KSF	20%
14	4h	CAN	50%
15		M-KSF	48%
16	4i	CAN	40%
17		M-KSF	52%
18	4j	CAN	38%
19		M-KSF	11%
20	4k	CAN	32%
21		M-KSF	25%
22	4l	CAN	31%
23		M-KSF	52%
24		M-K10	46%
25	4m	CAN	35%
26		M-KSF	6%
27	4n	CAN	43%
28		M-KSF	32%

Abbreviations: CAN = ceric ammonium nitrate; M-KSF = Montmorillonite KSF; M-K10 = Montmorillonite K10.