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Infectious Diseases in Obstetrics and Gynecology
Volume 1 (1994), Issue 5, Pages 235-241
Basic Science Article

Human Papillomaviruses and Papillomatosis Lesions of the Female Lower Genital Tract

1Guangzhou Maternal and Neonatal Hospital, Guangzhou, China
2Guangzhou Medicinal Institute, Guangzhou, China
3Sun Yat Sen University of Medical Sciences, Guangzhou, China
4Guangzhou Medical College, Guangzhou, China
5Guangzhou Maternal and Neonatal Hospital, 402 Renminzong Road, Guangzhou 510180, China

Received 14 September 1993; Accepted 15 January 1994

Copyright © 1994 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective: The objective of this study was to determine whether human papillomavirus (HPV) infections are involved in the development of papillomatosis lesions of the lower female genital tract.

Methods: A total of 616 biopsy specimens of genital papillomatous lesions (307 nodular and 309 papular types) from 598 patients were anaylyzed for the presence of HPV DNA sequences by polymerase chain reaction (PCR). These specimens were also examined by histopathological assessment for characteristic HPV-associated cytological changes, by immunohistochemical staining for HPV-associated antigen, and by electron microscopy for the presence of virions.

Results: HPV DNA sequences were found in 97.9% (140 of 143 cases) and 1.1% (1 of 91 cases) of the nodular and papular papillomatosis cases tested, respectively. In 18 patients who had both types of papillomatosis lesions, HPV DNA was invariably found only in nodular tissues. HPV-associated antigen, koilocytosis, and virions were found in 53.6% (98 of 183 cases), 70.5% (129 of 183 cases), and 5.9% (5 of 85 cases) of nodular papillomatosis lesions tested, respectively.

Conclusions: These data suggest that nodular papillomatosis was closely associated with HPV infection, but that papular papillomatosis of the lower female genital tract may have an etiology other than HPV infection,