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Infectious Diseases in Obstetrics and Gynecology
Volume 5, Issue 2, Pages 121-127

Immunopathogenesis of Toxoplasmosis in Pregnancy

Laboratoire de Parasitologie-Mycologie, UFR Cochin Port Royal, 27 rue du Faubourg St Jacques, Paris 75014, France

Received 1 October 1997; Accepted 21 October 1997

Copyright © 1997 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The immunopathogenesis of toxoplasmosis during pregnancy is not completely understood. This paper will try to discuss the most frequently asked questions about the immunopathogeny of congenital toxoplasmosis: differential virulence of Toxoplasma isolates, genetic susceptibility to infection, facilitation of placental transfer, models of congenital toxoplasmosis, and transmission in seropositive hosts. Most published data suggest a role of the genetic background of the host and of the parasite. Models of congenital toxoplasmosis have been evaluated, but it appears that the conclusion drawn would be barely appropriate to understand the pathogenesis in pregnant women.