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Infectious Diseases in Obstetrics and Gynecology
Volume 6, Issue 1, Pages 8-12
Clinical Study

Chlamydial Lower Genital Tract Infection and Spontaneous Abortion

Department of Epidemiology, University of Pittsburgh, Graduate School of Public Health, 130 DeSoto Street, 517 Parran Hall, Pittsburgh, PA 15261, USA

Received 23 September 1997; Accepted 25 February 1998

Copyright © 1998 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective: Few previous studies have examined the role that acute Chlamydia trachomatis lower genital tract infection plays in the development of spontaneous abortion. This study evaluated cervical C. trachomatis infections among 52 women experiencing spontaneous abortion and 59 controls.

Methods: Pregnant women at less than 22 weeks of gestation who sought medical care in an emergency department in West Philadelphia were eligible for enrollment. Urine samples from enrolled women were tested for chlamydia using ligase chain reaction DNA amplification. All women were followed up to 22 weeks of pregnancy to ascertain the outcome of spontaneous abortion.

Results: The proportion of women with chlamydial infection was 3.8% among spontaneous abortion cases and 8.5% among controls. After adjustment for potentially confounding factors, there was no substantial difference in the rate of chlamydial infection between women with and without spontaneous abortion (odds ratio 1.8, 95% confidence interval 0.3–10.7).

Conclusion: These data do not support a relationship between acute C. trachomatis infection and the development of spontaneous abortion.