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Infectious Diseases in Obstetrics and Gynecology
Volume 7 (1999), Issue 1-2, Pages 49-54
http://dx.doi.org/10.1155/S1064744999000101

Immunity to Heat Shock Proteins and Arthritic Disorders

Institute of Infectious Diseases and Immunology, Utrecht University, Yalelaan 1, Utrecht 3584 CL, The Netherlands

Copyright © 1999 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Adjuvant arthritis (AA) is a frequently used model of experimental arthritis. Because of its histopathology, which is reminiscent of rheumatoid arthritis in humans, AA is used as a model for the development of novel anti-inflammatory drugs. Recently, it has become evident that AA is a typical T-cell-mediated autoimmune condition. Therefore, novel immunotherapies targeted to T cells can be developed in this model. Analysis of responding T cells in AA have now led to the definition of various antigens with potential relevance to arthritis, including human arthritic conditions. One such antigen defined in AA is the 60kD heat shock protein. Both T-cell vaccination approaches and active antigen immunizations and antigen toleration approaches have turned out to be effective in suppressing AA. Infect. Dis. Obstet. Gynecol. 7:49–54, 1999.