Infectious Diseases in Obstetrics and Gynecology

Infectious Diseases in Obstetrics and Gynecology / 2000 / Article

Open Access

Volume 8 |Article ID 326907 | https://doi.org/10.1155/S1064744900000326

Brian Casey, Roger E. Bawdon, "Ex Vivo Human Placental Transfer of Trovafloxacin", Infectious Diseases in Obstetrics and Gynecology, vol. 8, Article ID 326907, 2 pages, 2000. https://doi.org/10.1155/S1064744900000326

Ex Vivo Human Placental Transfer of Trovafloxacin

Received14 Jun 2000
Accepted15 Sep 2000

Abstract

Objective: The purpose of this study was to determine the ex vivo human placental transfer of trovafloxacin from the maternal circulation to the fetal circulation.Methods: Six placentas from uncomplicated, term, vaginal or cesarean deliveries were studied using the ex vivo isolated cotyledon perfusion chamber; C14-antipyrine was used as a reference compound to determine the clearance index (CI) of trovafloxacin.Results: The CI of trovafloxacin was 0.19 ± 0.13 at a mean trough concentration of 1.38 ± 0.22 μg/ml and 0.16 ± 0.10 at a mean peak concentration of 7.48 ± 2.3 μg/ml as determined by our newly developed high-pressure liquid chromatographic assay. Tissue concentration did not exceed maternal concentration, and there was little or no accumulation when the perfusion system was closed for 1 hr.Conclusions: Trovafloxacin crosses the placenta by simple diffusion and does not accumulate in the media to any extent, nor does it bind to tissue or accumulate in the placenta. Infect. Dis. Obstet. Gynecol. 8:228–229, 2000.

Copyright © 2000 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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