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Infectious Diseases in Obstetrics and Gynecology
Volume 10 (2002), Issue 3, Pages 159-160

Varicella Vaccination During Early Pregnancy: A Cause of in utero Miliary Fetal Tissue Calcifications and Hydrops?

Department of Obstetrics, Gynecology and Women’s Health, New Jersey Medical School, l85 South Orange Avenue, MSB, E-506 Newark, Newark, NJ 07103-2714, USA

Received 7 February 2002; Accepted 29 May 2002

Copyright © 2002 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background: It is the purpose of this article to describe a suspected association of inadvertent vaccination with varicella vaccine during early pregnancy with the subsequent development of in utero miliary fetal tissue calcifications and fetal hydrops detected by sonogram at 15 weeks of gestation.

Case: This is a case presentation of a pregnant patient who received varicella vaccination during the same menstrual cycle that she became pregnant, and is supplemented by a literary review. The fetus developed miliary fetal tissue calcifications and fetal hydrops detected by a targeted sonogram at 15 weeks gestation.

Conclusion: Varicella vaccination during early pregnancy may be a cause of miliary fetal tissue calcifications and fetal hydrops.