Infectious Diseases in Obstetrics and Gynecology

Infectious Diseases in Obstetrics and Gynecology / 2002 / Article

Open Access

Volume 10 |Article ID 279852 |

A. P. Murtha, R. Auten, W. N. P. Herbert, "Apoptosis in the Chorion Laeve of Term Patients With Histologic Chorioamnionitis", Infectious Diseases in Obstetrics and Gynecology, vol. 10, Article ID 279852, 4 pages, 2002.

Apoptosis in the Chorion Laeve of Term Patients With Histologic Chorioamnionitis

Received14 Sep 2001
Accepted28 Dec 2001


Objective: The balance between cell survival and cell death (apoptosis) is critical during development and may affect organ function. Apoptosis is accelerated in the presence of infection and inflammation in a variety of organ systems. The objective of this investigation was to determine if apoptosis was increased in the chorion laeve of term patients with and without histologic chorioamnionitis.Methods: Records of placental pathology were reviewed with respect to the presence/absence of histologic chorioamnionitis. Sections from formalin-fixed, paraffin-embedded fetal membrane rolls were stained using the TUNEL method. The proportion of apoptotic nuclei was calculated in seven high-powered fields/section. Those with and without histologic chorioamnionitis were compared. Datawere analyzed using the Mann—Whitney U test, with significance defined as p < 0.05.Results: There was no significant difference in demographic or clinical characteristics between the two groups. The chorion laeve from subjects with histologic chorioamnionitis had significantly more apoptotic nuclei when compared to those without chorioamnionitis (11.2% vs. 5%, p = 0.02).Conclusion: Apoptosis ismore prevalent in the chorion laeve of fetal membranes with histologic chorioamnionitis. This finding suggests that infection/inflammation may impact cell survivalwithin fetal membranes. The implications of these findings warrant further investigation.

Copyright © 2002 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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