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Infectious Diseases in Obstetrics and Gynecology
Volume 2007, Article ID 35387, 8 pages
http://dx.doi.org/10.1155/2007/35387
Clinical Study

Phase I Trial of a Lactobacillus crispatus Vaginal Suppository for Prevention of Recurrent Urinary Tract Infection in Women

Division of Allergy and Infectious Diseases, University of Washington School of Medicine, Seattle, WA 98195, USA

Received 15 June 2007; Accepted 26 September 2007

Copyright © 2007 Christopher A. Czaja et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. B. Foxman, R. Barlow, H. D'Arcy, B. Gillespie, and J. D. Sobel, “Urinary tract infection: self-reported incidence and associated costs,” Annals of Epidemiology, vol. 10, no. 8, pp. 509–515, 2000. View at Publisher · View at Google Scholar
  2. B. Foxman, “Recurring urinary tract infection: incidence and risk factors,” American Journal of Public Health, vol. 80, no. 3, pp. 331–333, 1990. View at Google Scholar
  3. W. E. Stamm and T. M. Hooton, “Management of urinary tract infections in adults,” New England Journal of Medicine, vol. 329, no. 18, pp. 1328–1334, 1993. View at Publisher · View at Google Scholar
  4. K. Gupta, D. Scholes, and W. E. Stamm, “Increasing prevalence of antimicrobial resistance among uropathogens causing acute uncomplicated cystitis in women,” Journal of the American Medical Association, vol. 281, no. 8, pp. 736–738, 1999. View at Publisher · View at Google Scholar
  5. D. A. Eschenbach, P. R. Davick, B. L. Williams et al., “Prevalence of hydrogen peroxide-producing Lactobacillus species in normal women and women with bacterial vaginosis,” Journal of Clinical Microbiology, vol. 27, no. 2, pp. 251–256, 1989. View at Google Scholar
  6. S. E. Hawes, S. L. Hillier, J. Benedetti et al., “Hydrogen peroxide-producing lactobacilli and acquisition of vaginal infections,” Journal of Infectious Diseases, vol. 174, no. 5, pp. 1058–1063, 1996. View at Google Scholar
  7. H. L. Martin, B. A. Richardson, P. M. Nyange et al., “Vaginal lactobacilli, microbial flora, and risk of human immunodeficiency virus type 1 and sexually transmitted disease acquisition,” Journal of Infectious Diseases, vol. 180, no. 6, pp. 1863–1868, 1999. View at Publisher · View at Google Scholar
  8. M. A. D. Antonio, S. E. Hawes, and S. L. Hillier, “The identification of vaginal Lactobacillus species and the demographic and microbiologic characteristics of women colonized by these species,” Journal of Infectious Diseases, vol. 180, no. 6, pp. 1950–1956, 1999. View at Publisher · View at Google Scholar
  9. K. Gupta, A. E. Stapleton, T. M. Hooton, P. L. Roberts, C. L. Fennell, and W. E. Stamm, “Inverse association of H202-producing lactobacilli and vaginal Escherichia coli colonization in women with recurrent urinary tract infections,” Journal of Infectious Diseases, vol. 178, no. 2, pp. 446–450, 1998. View at Google Scholar
  10. T. M. Hooton, P. L. Roberts, and W. E. Stamm, “Effects of recent sexual activity and use of a diaphragm on the vaginal microflora,” Clinical Infectious Diseases, vol. 19, no. 2, pp. 274–278, 1994. View at Google Scholar
  11. T. M. Hooton, S. Hillier, C. Johnson, P. L. Roberts, and W. E. Stamm, “Escherichia coli bacteriuria and contraceptive method,” Journal of the American Medical Association, vol. 265, no. 1, pp. 64–69, 1991. View at Publisher · View at Google Scholar
  12. G. Reid, A. W. Bruce, N. Fraser, C. Heinemann, J. Owen, and B. Henning, “Oral probiotics can resolve urogenital infections,” FEMS Immunology & Medical Microbiology, vol. 30, no. 1, pp. 49–52, 2001. View at Publisher · View at Google Scholar
  13. G. Reid, D. Beuerman, C. Heinemann, and A. W. Bruce, “Probiotic Lactobacillus dose required to restore and maintain a normal vaginal flora,” FEMS Immunology & Medical Microbiology, vol. 32, no. 1, pp. 37–41, 2001. View at Publisher · View at Google Scholar
  14. G. Reid, D. Charbonneau, J. Erb et al., “Oral use of Lactobacillus rhamnosus GR-1 and L. fermentum RC-14 significantly alters vaginal flora: randomized, placebo-controlled trial in 64 healthy women,” FEMS Immunology & Medical Microbiology, vol. 35, no. 2, pp. 131–134, 2003. View at Publisher · View at Google Scholar
  15. A. W. Bruce and G. Reid, “Intravaginal instillation of lactobacilli for prevention of recurrent urinary tract infections,” Canadian Journal of Microbiology, vol. 34, no. 3, pp. 339–343, 1988. View at Google Scholar
  16. G. Reid, A. W. Bruce, and M. Taylor, “Influence of three-day antimicrobial therapy and Lactobacillus vaginal suppositories on recurrence or urinary tract infections,” Clinical Therapeutics, vol. 14, no. 1, pp. 11–16, 1992. View at Google Scholar
  17. P. Cadieux, J. Burton, G. Gardiner et al., “Lactobacillus strains and vaginal ecology,” Journal of the American Medical Association, vol. 287, no. 15, pp. 1940–1941, 2002. View at Publisher · View at Google Scholar
  18. J. P. Burton, P. A. Cadieux, and G. Reid, “Improved understanding of the bacterial vaginal microbiota of women before and after probiotic instillation,” Applied and Environmental Microbiology, vol. 69, no. 1, pp. 97–101, 2003. View at Publisher · View at Google Scholar
  19. G. Reid, R. L. Cook, and A. W. Bruce, “Examination of strains of lactobacillis for properties that may influence bacterial interference in the urinary tract,” Journal of Urology, vol. 138, pp. 330–335, 1987. View at Google Scholar
  20. M. A. D. Antonio, S. E. Hawes, and S. L. Hillier, “The identification of vaginal Lactobacillus species and the demographic and microbiologic characteristics of women colonized by these species,” Journal of Infectious Diseases, vol. 180, no. 6, pp. 1950–1956, 1999. View at Publisher · View at Google Scholar
  21. A. Vasquez, T. Jakobsson, S. Ahrne, U. Forsum, and G. Molin, “Vaginal Lactobacillus flora of healthy Swedish women,” Journal of Clinical Microbiology, vol. 40, no. 8, pp. 2746–2749, 2002. View at Publisher · View at Google Scholar
  22. J. Osset, R. M. Bartolome, E. Garcia, and A. Andreu, “Assessment of the capacity of Lactobacillus to inhibit the growth of uropathogens and block their adhesion to vaginal epithelial cells,” Journal of Infectious Diseases, vol. 183, no. 3, pp. 485–491, 2001. View at Publisher · View at Google Scholar
  23. A. Andreu, A. E. Stapleton, C. L. Fennell, S. L. Hillier, and W. E. Stamm, “Hemagglutination, adherence, and surface properties of vaginal Lactobacillus species,” Journal of Infectious Diseases, vol. 171, no. 5, pp. 1237–1243, 1995. View at Google Scholar
  24. L. Kwok, A. E. Stapleton, W. E. Stamm, S. L. Hillier, C. L. Wobbe, and K. Gupta, “Adherence of Lactobacillus crispatus to vaginal epithelial cells from women with or without a history of recurrent urinary tract infection,” Journal of Urology, vol. 176, no. 5, pp. 2050–2054, 2006. View at Publisher · View at Google Scholar
  25. M. A. D. Antonio and S. L. Hillier, “DNA fingerprinting of Lactobacillus crispatus strain CTV-05 by repetitive element sequence-based PCR analysis in a pilot study of vaginal colonization,” Journal of Clinical Microbiology, vol. 41, no. 5, pp. 1881–1887, 2003. View at Publisher · View at Google Scholar
  26. W. E. Stamm, K. F. Wagner, R. Amsel et al., “Causes of the acute urethral syndrome in women,” New England Journal of Medicine, vol. 303, no. 8, pp. 409–415, 1980. View at Google Scholar
  27. E. V. Valore, D. J. Wiley, and T. Ganz, “Reversible deficiency of antimicrobial polypeptides in bacterial vaginosis,” Infection and Immunity, vol. 74, no. 10, pp. 5693–5702, 2006. View at Publisher · View at Google Scholar
  28. J. M. Marrazzo, R. L. Cook, H. C. Wiesenfeld et al., “Women's satisfaction with an intravaginal Lactobacillus capsule for the treatment of bacterial vaginosis,” Journal of Women's Health, vol. 15, no. 9, pp. 1053–1060, 2006. View at Publisher · View at Google Scholar
  29. S. Uehara, K. Monden, K. Nomoto, Y. Seno, R. Kariyama, and H. Kumon, “A pilot study evaluating the safety and effectiveness of Lactobacillus vaginal suppositories in patients with recurrent urinary tract infection,” International Journal of Antimicrobial Agents, vol. 28, 1, pp. 30–34, 2006. View at Publisher · View at Google Scholar