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Infectious Diseases in Obstetrics and Gynecology
Volume 2007 (2007), Article ID 92307, 6 pages
Research Article

Genital Tract Interleukin-8 but not Interleukin-1β or Interleukin-6 Concentration is Associated with Bacterial Vaginosis and Its Clearance in HIV-Infected and HIV-Uninfected Women

1Department of Pediatrics, Division of Infectious Diseases, Warren Alpert Medical School, Brown University, Providence, RI 02912, USA
2Hasbro Children's Hospital, Providence, RI 02903, USA
3Laboratory of Genital Tract Biology, Brigham and Women's Hospital, Department of Obstetrics and Gynecology, Harvard Medical School, Boston, MA 02115, USA
4Center for Statistical Sciences, Brown University, Providence, RI 02912, USA
5Miriam Hospital, Providence, RI 02906, USA
6Department of Medicine, Division of Infectious Diseases, Warren Alpert Medical School, Brown University, Providence, RI 02912, USA

Received 22 May 2007; Accepted 5 July 2007

Copyright © 2007 Phyllis Losikoff et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Genital tract infections and cytokine perturbations are associated with increased HIV acquisition and transmission. We measured the relationship between bacterial vaginosis (BV) and concentrations of Interleukin-8 (IL-8), Interleukin-1β (IL-1β), and Interleukin-6 (IL-6) in cervicovaginal lavage (CVL) specimens collected longitudinally from 16 HIV-infected and 8 HIV-uninfected high-risk women. CVL samples were analyzed when women presented with BV, and at their next visit, after successful treatment, when BV was cleared. A subset of participants had cytokine levels evaluated at three consecutive clinic visits: before developing BV, at the time of BV diagnosis, and after clearing BV. Significantly higher IL-8, but not IL-1β or IL-6 levels were present when women had active BV compared to when BV was absent. Trends in cytokine levels were similar for HIV-infected and HIV-uninfected women. BV in these women was associated with significantly higher concentrations of genital tract IL-8 which decreased 2.4 fold when BV was cleared.