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Infectious Diseases in Obstetrics and Gynecology
Volume 2009, Article ID 198425, 4 pages
http://dx.doi.org/10.1155/2009/198425
Research Article

Human Papillomavirus Type Distribution and Correlation with Cyto-Histological Patterns in Women from the South of Italy

1Department of Virology and Molecular Biology, Laboratory “Dr. P. Pignatelli”, Via Martiri d'Otranto, 2, 73100 Lecce, Italy
2Department of Histology, Microbiology, and Medical Biotechnologies, University of Padova, 35121 Padova, Italy

Received 17 June 2009; Revised 5 November 2009; Accepted 3 December 2009

Academic Editor: Kenneth Fife

Copyright © 2009 Paola Menegazzi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Human papillomavirus (HPV) type-specific distribution was evaluated in genital samples collected from 654 women from the South of Italy undergoing voluntary screening and correlated with cyto-histological abnormalities. HPV DNA was detected in 45.9% of the samples, 41.7% of which had multiple infection and 89.0% had high-risk HPV infection. The prevalence of HPV infection and the rate of multiple infections decreased with age, suggesting natural selection of HPV types with better fitness. In line with other Italian studies, the most common HPV types were HPV-6 and HPV-16, followed by HPV-51, HPV-31, HPV-53, and HPV-66, in women with both normal and abnormal cytology. Cervical intraepithelial lesions grade 2 or 3 were associated with high-risk HPV-16, HPV-18, HPV-31, and HPV-51 infection. These data indicate that prophylactic HPV vaccination is expected to reduce the burden of HPV-related cervical lesions in this population, but also suggest the potential utility of new vaccines with larger type coverage.