Kinetics and Determining Factors of the Virologic Response to Antiretrovirals during Pregnancy
Kinetics of the plasma HIV RNA in pregnant women on HAART. Data were derived from 76 pregnant women who initiated or reinitiated HAART during pregnancy. 0 weeks indicates the beginning of therapy. Grey lines represent individual plasma HIV RNA trajectories. The black line represents the population curve generated by the mixed-model analysis. The predictions of the model were confirmed by additional analyses which showed that at 4 weeks of HAART, 42% of mothers had 100 HIV RNA copies/mL of plasma; at 12 weeks, 42% had 50 copies/mL; and at 24 weeks, 56% had 50 copies/mL. However, it should be noted that the model’s estimated rise between 5 and 7 weeks is likely not real.
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