Kinetics and Determining Factors of the Virologic Response to Antiretrovirals during Pregnancy

Table 3

Distribution of therapeutic drug monitoring results of protease inhibitors during pregnancy.

	All	LPVr	NFV	SAQr	IDVr	RTV
1st trimester	7	4	2	1	0	0
Low	2 (29)	1 (25)	1	0	0	0
Normal	4 (57)	3 (75)	1	0	0	0
High	1 (14)	0	0	1	0	0
2nd trimester	57	28	17	10	0	2
Low	20 (35)	7 (25)	6 (35)	5 (50)	0	2
Normal	34 (60)	21 (75)	10 (59)	3 (30)	0	0
High	3 (5)	0	1 (6)	2 (20)	0	0
3rd trimester	18	5	5	4	2	2
Low	8 (44)	1 (20)	4 (80)	2 (50)	1	0
Normal	9 (50)	4 (75)	1 (20)	2 (50)	0	2
High	1 (6)	0	0	0	1	0

Numbers (%) represent pregnant women taking PI doses recommended for adults.
Abbreviations: IDVr = indinavir/ritonavir; LPVr = lopinavir/ritonavir; NFV = nelfinavir; RTV = ritonavir; SAQr = saquinavir/ritonavir.