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Infectious Diseases in Obstetrics and Gynecology
Volume 2010 (2010), Article ID 802503, 7 pages
Clinical Study

Hepatitis B Response of Premature Infants after Primary and Booster Immunisation with a Diphtheria-Tetanus-Acellular Pertussis-Hepatitis B-Inactivated Poliovirus/Haemophilus Influenzae Type B Vaccine

1Neonatal Unit, Department of Neonatology, La Paz Hospital, Castellana 261, 28046 Madrid, Spain
2Department of Paediatrics, La Paz Hospital, 28046 Madrid, Spain
3Medical Department, GlaxoSmithKline, Tres Cantos, Madrid, Spain

Received 1 December 2009; Accepted 4 March 2010

Academic Editor: José Tirán-Saucedo

Copyright © 2010 Felix Omeñaca et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A range of schedules are recommended for hepatitis B vaccination of premature infants. This open-label study (217744/083) compared the immune response of premature ( ) and full-term infants ( ) to hepatitis B antigen following primary administration of hexavalent DTPa-HBV-IPV/Hib vaccine at 2–4–6 months and a booster dose at 18 months. Anti-HBsAg antibodies were determined before and one month after primary and booster doses. There were no significant differences in postprimary seroprotection rates (anti-HBsAg >10 mIU/mL; preterm 93.4%; full-term 95.2%) or geometric mean concentrations (634 versus 867 mIU/ml), and neither appeared to be related to gestational length or birth weight. Prebooster seroprotection rates were 75 and 80.6%, respectively. Six premature infants did not respond to primary and booster doses. Primary and booster vaccinations with DTPa-HBV-IPV/Hib elicit satisfactory anti-HBsAg responses in preterm infants, which are not influenced by gestational age or birth weight. This schedule and vaccine will greatly facilitate the immunisation of premature infants.