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Infectious Diseases in Obstetrics and Gynecology
Volume 2011 (2011), Article ID 157680, 4 pages
http://dx.doi.org/10.1155/2011/157680
Research Article

Genital HSV Detection among HIV-1-Infected Pregnant Women in Labor

1Division of Neonatology, Department of Pediatrics, University of Washington, P.O. Box 356320, Seattle, WA 98195-6320, USA
2Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195-6320, USA
3Department of Laboratory Medicine, University of Washington, Seattle, WA 98195-6320, USA
4Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
5Pediatric, Adolescent and Maternal AIDS Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, MD 20847, USA
6Department of Medicine, University of Washington, Seattle, WA 98195-6320, USA
7Department of Epidemiology, University of Washington, Seattle, WA 98195-6320, USA

Received 28 October 2010; Accepted 13 January 2011

Academic Editor: Grace John-Stewart

Copyright © 2011 Janna Patterson et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To compare genital HSV shedding among HIV-positive and HIV-negative women. Methods. Women with and without known HIV infection who delivered at the University of Washington Medical Center between 1989–1996 had HSV serologies done as part of clinical care. Genital swabs from HSV-2-seropositive women were evaluated by real-time quantitative HSV DNA PCR. Results. HSV-2 seroprevalence was 71% and 30% among 75 HIV-positive and 3051 HIV-negative women, respectively, ( ). HSV was detected at delivery in the genital tract of 30.8% of HIV-seropositive versus 9.5% of HIV-negative women ( , 95% CI 1.6 to 6.5, ). The number of virion copies shed per mL was similar (log 3.54 for HIV positive versus 3.90 for HIV negative, ). Conclusions. Our study demonstrated that HIV-, HSV-2-coinfected women are more likely to shed HSV at delivery.