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Infectious Diseases in Obstetrics and Gynecology
Volume 2011, Article ID 216217, 7 pages
Research Article

Maternal Vitamin D, Folate, and Polyunsaturated Fatty Acid Status and Bacterial Vaginosis during Pregnancy

1Department of Family & Preventive Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
2Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA 30322, USA
3Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
4Perinatal Research Center, Women’s Health Research and Education Foundation, Nashville, TN 37203-1538, USA
5Division of Maternal-Fetal Medicine Perinatal Research, Department of Obstetrics & Gynecology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1062, USA

Received 22 August 2011; Accepted 25 October 2011

Academic Editor: Michael G. Gravett

Copyright © 2011 Anne L. Dunlop et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To investigate associations among serum 25-hydroxy-vitamin D (25-OH-D), folate, omega-6/omega-3 fatty acid ratio and bacterial vaginosis (BV) during pregnancy. Methods. Biospecimens and data were derived from a random sample (N=160) of women from the Nashville Birth Cohort. We compared mean plasma nutrient concentrations for women with and without BV during pregnancy (based on Nugent score ≥7) and assessed the odds of BV for those with 25-OH-D <12 ng/mL, folate <5 ug/L, and omega-6/omega-3 ratio >15. Results. The mean plasma 25-OH-D was significantly lower among women with BV during pregnancy (18.00±8.14 ng/mL versus 24.34±11.97 ng/mL, P=0.044). The adjusted odds of BV were significantly increased among pregnant women with 25-OH-D <12 ng/mL (aOR 5.11, 95% CI: 1.19–21.97) and folate <5 ug/L (aOR 7.06, 95% CI: 1.07–54.05). Conclusion. Vitamin D and folate deficiencies were strongly associated with BV (Nugent score ≥7) during pregnancy.