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Infectious Diseases in Obstetrics and Gynecology
Volume 2011 (2011), Article ID 675360, 7 pages
Review Article

Nonhuman Primate Models Used to Study Pelvic Inflammatory Disease Caused by Chlamydia trachomatis

1Department of Obstetrics & Gynecology, University of Michigan, 1500 East Medical Center Drive, L4510, Ann Arbor, MI 48109, USA
2Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
3College of Literature, Science, and the Arts, University of Michigan, Ann Arbor, MI 48109, USA
4Reproductive Sciences Program and the Division of Infectious Diseases, Department of Internal Medicine, Department of Microbiology & Immunology, University of Michigan, Ann Arbor, MI 48109, USA
5Department of Obstetrics & Gynecology, University of Washington, Seattle, WA 98195, USA

Received 15 May 2011; Accepted 3 June 2011

Academic Editor: Thomas Cherpes

Copyright © 2011 Jason D. Bell et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Pelvic inflammatory disease (PID) is a global health concern that is associated with significant morbidity and is a major cause of infertility. Throughout history animals have been used for anatomical studies and later as models of human disease. In particular, nonhuman primates (NHPs) have permitted investigations of human disease in a biologically, physiologically, and anatomically similar system. The use of NHPs as human PID models has led to a greater understanding of the primary microorganisms that cause disease (e.g., Chlamydia trachomatis and Neisseria gonorroheae), the pathogenesis of infection and its complications, and the treatment of people with PID. This paper explores historical and contemporary aspects of NHP modeling of chlamydial PID, with an emphasis on advantages and limitations of this approach and future directions for this research.