Research Article
Clinicopathological Comparison of Adenocarcinoma of Cervix and Endometrium Using Cell Cycle Markers: P16ink4a, P21waf1, and p27Kip1 on 132 Cancers
Table 6
Associations between p27Kip1 expression and clinicopathologic parameter for endocervical adenocarcinoma.
| | Characteristics | No. of patients | Positive, (%) () | Negative, (%) () | value |
| | Age (years) | | | | | | <35 | 3 | 2 (66.7) | 1 (33.3) | 0.292 | | 35–54 | 22 | 7 (31.8) | 15 (68.2) | | ≥55 | 15 | 8 (53.3) | 7 (46.7) |
| | FIGO stage | | | | | | I-II | 30 | 15 (50.0) | 15 (50.0) | 0.097 | | III-IV | 10 | 2 (20.0) | 8 (80.0) |
| | Histology tumor differentiation | | | | | | Well/moderate | 25 | 11 (44.0) | 14 (56.0) | 0.804 | | Poor | 15 | 6 (40.0) | 9 (60.0) |
| | Infiltration depth | | | | | | Inner 2/3 | 13 | 5 (38.5) | 8 (61.5) | 0.720 | | Outer 1/3 or through | 27 | 12 (44.4) | 15 (55.6) |
| | Tumor length | | | | | | <20 mm | 11 | 5 (45.5) | 6 (54.5) | 0.818 | | >20 mm | 29 | 12 (41.4) | 17 (58.6) |
| | Tumor thickness | | | | | | <5 mm | 4 | 1 (25.0) | 3 (75.0) | 0.395 | | >5 mm | 36 | 16 (44.4) | 20 (55.6) |
| | Infiltration to corpus | | | | | | Yes | 17 | 6 (35.3) | 11 (64.7) | 0.428 | | No | 23 | 11 (47.8) | 12 (52.2) |
| | Vascular invasion | | | | | | Yes | 20 | 7 (35.0) | 13 (65.0) | 0.337 | | No | 20 | 10 (50.0) | 10 (50.0) |
| | Lymph node invasion | | | | | | Yes | 12 | 2 (16.7) | 10 (83.3) | 0.030 | | No | 28 | 15 (53.6) | 13 (46.4) |
| | Histologic type | | | | | | Endocervical | 25 | 9 (36.0) | 16 (64.0) | 0.283 | | Non endocervical | 15 | 8 (53.3) | 7 (46.7) |
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