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Infectious Diseases in Obstetrics and Gynecology
Volume 2012 (2012), Article ID 921519, 8 pages
http://dx.doi.org/10.1155/2012/921519
Clinical Study

Diaphragm Used with Replens Gel and Risk of Bacterial Vaginosis: Results from a Randomized Controlled Trial

1Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, 50 Beale Street, Suite 1200, San francisco, CA 94105, USA
2Department of Biostatistics, University of California, San Francisco, 50 Beale Street, Suite 1200, San Francisco, CA 94105, USA
3University of Zimbabwe-UCSF Collaborative Research Programme, 15 Phillips Ave, Belgravia, Harare, Zimbabwe
4Centre for Microbiology Research, Kenya Medical Research Institute, P.O. Box 54840-00200, Nairobi, Kenya
5African Medical and Research Foundation, Clinical and Diagnostics Programme, P.O. Box 27691-00506, Nairobi, Kenya
6School of Public Health, University of California at Berkeley, 50 University Hall, MC 7360, Berkeley, CA 94720-7360, USA
7Women’s Global Health Imperative, RTI International, 114 Sansome Street, San Francisco, CA 94104, USA

Received 2 July 2012; Accepted 26 September 2012

Academic Editor: Deborah B. Nelson

Copyright © 2012 Craig R. Cohen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. T. L. Cherpes, L. A. Meyn, M. A. Krohn, J. G. Lurie, and S. L. Hillier, “Association between acquisition of herpes simplex virus type 2 in women and bacterial vaginosis,” Clinical Infectious Diseases, vol. 37, no. 3, pp. 319–325, 2003. View at Publisher · View at Google Scholar · View at Scopus
  2. C. R. Cohen, A. Duerr, N. Pruithithada et al., “Bacterial vaginosis and HIV seroprevalence among female commercial sex workers in chiang mai, thailand,” AIDS, vol. 9, no. 9, pp. 1093–1097, 1995. View at Google Scholar · View at Scopus
  3. N. Sewankambo, R. H. Gray, M. J. Wawer et al., “HIV-1 infection associated with abnormal vaginal flora morphology and bacterial vaginosis,” The Lancet, vol. 350, no. 9093, pp. 546–550, 1997. View at Google Scholar · View at Scopus
  4. C. R. Cohen, J. R. Lingappa, J. M. Baeten et al., “Bacterial vaginosis associated with increased risk of female-to-male HIV-1 transmission: a prospective cohort analysis among African couples,” PLoS Medicine, vol. 9, no. 6, Article ID e1001251, 2012. View at Google Scholar
  5. E. A. Bukusi, C. R. Cohen, A. S. Meier et al., “Bacterial vaginosis: risk factors among kenyan women and their male partners,” Sexually Transmitted Diseases, vol. 33, no. 6, pp. 361–367, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. S. J. Klebanoff, S. L. Hillier, D. A. Eschenbach, and A. M. Waltersdorph, “Control of the microbial flora of the vagina by H2O2-generating lactobacilli,” Journal of Infectious Diseases, vol. 164, no. 1, pp. 94–100, 1991. View at Google Scholar · View at Scopus
  7. F. B. Hashemi, M. Ghassemi, S. Faro, A. Aroutcheva, and G. T. Spear, “Induction of human immunodeficiency virus type 1 expression by anaerobes associated with bacterial vaginosis,” Journal of Infectious Diseases, vol. 181, no. 5, pp. 1574–1580, 2000. View at Publisher · View at Google Scholar · View at Scopus
  8. F. B. Hashemi, M. Ghassemi, K. A. Roebuck, and G. T. Spear, “Activation of human immunodeficiency virus type 1 expression by Gardnerella vaginalis,” Journal of Infectious Diseases, vol. 179, no. 4, pp. 924–930, 1999. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Rebbapragada, K. Howe, C. Wachihi et al., “Bacterial vaginosis in HIV-infected women induces reversible alterations in the cervical immune environment,” Journal of Acquired Immune Deficiency Syndromes, vol. 49, no. 5, pp. 520–522, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Bolton, A. van der Straten, and C. R. Cohen, “Probiotics: potential to prevent HIV and sexually transmitted infections in women,” Sexually Transmitted Diseases, vol. 35, no. 3, pp. 214–225, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. J. Sobel, J. F. Peipert, J. A. McGregor et al., “Efficacy of clindamycin vaginal ovule (3-day treatment) vs. clindamycin vaginal cream (7-day treatment) in bacterial vaginosis,” Infectious Diseases in Obstetrics and Gynecology, vol. 9, no. 1, pp. 9–15, 2001. View at Google Scholar · View at Scopus
  12. J. D. Sobel, W. Chaim, J. Thomason et al., “Comparative study of intravaginal metronidazole and triple-sulfa therapy for bacterial vaginosis,” Infectious Diseases in Obstetrics and Gynecology, vol. 4, no. 2, pp. 66–70, 1996. View at Google Scholar
  13. J. D. Sobel, C. Schmitt, and C. Meriwether, “Long-term follow-up of patients with bacterial vaginosis treated with oral metronidazole and topical clindamycin,” Journal of Infectious Diseases, vol. 167, no. 3, pp. 783–784, 1993. View at Google Scholar · View at Scopus
  14. M. J. Wawer, R. H. Gray, N. K. Sewankambo et al., “A randomized, community trial of intensive sexually transmitted disease control for AIDS prevention, rakai, uganda,” AIDS, vol. 12, no. 10, pp. 1211–1225, 1998. View at Publisher · View at Google Scholar · View at Scopus
  15. K. Gupta, S. L. Hillier, T. M. Hooton, P. L. Roberts, and W. E. Stamm, “Effects of contraceptive method on the vaginal microbial flora: a prospective evaluation,” Journal of Infectious Diseases, vol. 181, no. 2, pp. 595–601, 2000. View at Publisher · View at Google Scholar · View at Scopus
  16. T. M. Hooton, P. L. Roberts, and W. E. Stamm, “Effects of recent sexual activity and use of a diaphragm on the vaginal microflora,” Clinical Infectious Diseases, vol. 19, no. 2, pp. 274–278, 1994. View at Google Scholar · View at Scopus
  17. J. van De Wijgert, A. Fullem, C. Kelly et al., “Phase 1 trial of the topical microbicide buffergel: safety results from four international sites,” Journal of Acquired Immune Deficiency Syndromes, vol. 26, no. 1, pp. 21–27, 2001. View at Google Scholar · View at Scopus
  18. M. Milani, E. Barcellona, and A. Agnello, “Efficacy of the combination of 2 g oral tinidazole and acidic buffering vaginal gel in comparison with vaginal clindamycin alone in bacterial vaginosis: a randomized, investigator-blinded, controlled trial,” European Journal of Obstetrics Gynecology and Reproductive Biology, vol. 109, no. 1, pp. 67–71, 2003. View at Publisher · View at Google Scholar · View at Scopus
  19. N. S. Padian, A. van der Straten, G. Ramjee et al., “Diaphragm and lubricant gel for prevention of HIV acquisition in southern african women: a randomised controlled trial,” The Lancet, vol. 370, no. 9583, pp. 251–261, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. R. P. Nugent, M. A. Krohn, and S. L. Hillier, “Reliability of diagnosing bacterial vaginosis is improved by a standardized method of gram stain interpretation,” Journal of Clinical Microbiology, vol. 29, no. 2, pp. 297–301, 1991. View at Google Scholar · View at Scopus
  21. A. van der Straten, S. Shiboski, E. T. Montgomery et al., “Patterns and predictors of adherence to diaphragm use in a phase III trial in sub-saharan africa: a trajectory analysis,” Journal of Acquired Immune Deficiency Syndromes, vol. 50, no. 4, pp. 419–426, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. A. van der Straten, H. Cheng, J. Moore et al., “The use of the diaphragm instead of condoms in a phase III diaphragm trial,” AIDS and Behavior, vol. 13, no. 3, pp. 564–572, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. J. Sánchez, P. E. Campos, B. Courtois et al., “Prevention of sexually transmitted diseases (STDs) in female sex workers: prospective evaluation of condom promotion and strengthened STD services,” Sexually Transmitted Diseases, vol. 30, no. 4, pp. 273–279, 2003. View at Publisher · View at Google Scholar · View at Scopus
  24. S. Sanchez, P. J. Garcia, K. K. Thomas, M. Catlin, and K. K. Holmes, “Intravaginal metronidazole gel versus metronidazole plus nystatin ovules for bacterial vaginosis: a randomized controlled trial,” American Journal of Obstetrics and Gynecology, vol. 191, no. 6, pp. 1898–1906, 2004. View at Publisher · View at Google Scholar · View at Scopus
  25. A. van der Straten, S. Napierala, H. Cheng et al., “A randomized controlled safety trial of the diaphragm and cellulose sulfate microbicide gel in sexually active women in zimbabwe,” Contraception, vol. 76, no. 5, pp. 389–399, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. G. Soboll, T. M. Schaefer, and C. R. Wira, “Effect of toll-like receptor (TLR) agonists on TLR and microbicide expression in uterine and vaginal tissues of the mouse,” American Journal of Reproductive Immunology, vol. 55, no. 6, pp. 434–446, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. S. S. Witkin, I. M. Linhares, and P. Giraldo, “Bacterial flora of the female genital tract: function and immune regulation,” Best Practice and Research, vol. 21, no. 3, pp. 347–354, 2007. View at Publisher · View at Google Scholar · View at Scopus
  28. B. Molteni, A. D'Antuono, P. Bandini et al., “Efficacy and tolerability of a new chlorhexidine-based vaginal gel in vaginal infections,” Current Medical Research and Opinion, vol. 20, no. 6, pp. 849–853, 2004. View at Publisher · View at Google Scholar · View at Scopus