Benzoyl Peroxide Formulated Polycarbophil/Carbopol 934P Hydrogel with Selective Antimicrobial Activity, Potentially Beneficial for Treatment and Prevention of Bacterial Vaginosis
Influence of pH on growth of G. vaginalis (a), L. vaginalis (b), L. gasseri (c), L. plantarum (d), and L. acidophilus (e). Microbial growth was evaluated in media with pH altered to the average pH of the gels (4.5) by HCl (●, ○), lactic acid (▲, Δ), and normal growth medium (■, □) (MRS for lactobacilli spp. and BHI + 3% HS for G. vaginalis). Sterile broth (◆) was also shown as negative control. Data were collected hourly (shown only 0, 1, 3, 6, 9, 12, 18, and 24 h measurements). Experiments were conducted twice in quadruplicate.
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