Research Article

Antenatal Atazanavir: A Retrospective Analysis of Pregnancies Exposed to Atazanavir

Table 2

Proportion of women achieving an HIV viral load <50  copies/mL by treatment regimen at time of delivery.

* HIV viral load <50  copies/mL 
%  
(95% CI)

All regimens12280.3% 
(72.1–86.6%)
ATV 300/R throughout**10183.2% 
(74.3–89.4%)
ATV 400/R escalated***1172.7% 
(33.5–93.4%)
ATV 400 throughout750% 
(11.0–89.0%)
ATV >4002100% 
(15.8–100%)
ATV 400 (reduced to 300/R)1100% 
(2.5–100%)

: number of pregnancies in which women were taking the specified regimen at the time of delivery.
**ATV 300/R throughout: women were prescribed atazanavir 300 mg/ritonavir 100 mg at all times when an atazanavir based regimen was prescribed in the recorded pregnancy.
***ATV 400/R escalated: women prescribed atazanavir 300 mg/ritonavir 100 mg initially; then dose increased to atazanavir 400 mg/ritonavir 100 mg in the third trimester.
ATV 400 throughout: women prescribed atazanavir 400 mg without ritonavir throughout pregnancy.
ATV >400 two pregnancies, both occurring in the same woman, where a dose of atazanavir >400 mg was prescribed without ritonavir boosting.
ATV 400 (reduced to 300/R): women prescribed atazanavir 400 mg without ritonavir at the start of pregnancy which was converted to atazanavir 300 mg/ritonavir 100 mg.