The Use of Protease Inhibitors in Pregnancy: Maternal and Fetal Considerations

Table 4

Unadjusted and adjusted odds ratios for pregnancy outcomes in HIV-infected women according to type of antepartum antiretroviral therapy.

	Unadjusted; odds ratio	Adjusted; odds ratio
Preterm birth <37 weeks
ART without protease inhibitor	1.0 (0.6, 1.5)	0.9 (0.5, 1.5)
No ART	1.7 (1.1, 2.6)	1.0 (0.5, 2.0)
SGA
ART without protease inhibitor	1.3 (0.9, 1.8)	1.3 (0.8, 1.9)
No ART	1.2 (0.8, 1.8)	1.1 (0.6, 2.0)

Logistic regression was performed to adjust for ethnicity, age, and duration of diagnosis, as well as viral load and CD4 cell count at both presentation for care and delivery.
Data reported as odds ratio (95% confidence interval) for women who received the indicated therapy as compared to women receiving a protease inhibitor.
SGA: small-for-gestational-age, defined as less than 10th percentile for gestational age.