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Infectious Diseases in Obstetrics and Gynecology
Volume 2018, Article ID 1426109, 9 pages
Research Article

Benzoyl Peroxide Inhibits Quorum Sensing and Biofilm Formation by Gardnerella vaginalis 14018

1Department of Biochemistry and Microbiology, Rutgers State University, New Brunswick, NJ, USA
2Department of Biology and Biotechnology, College of Sciences, Diyala University, Baqubah, Iraq
3Department of Life Sciences and Technology, Beuth University of Applied Sciences, Berlin, Germany
4Health Promoting Natural Laboratory, School of Environmental and Biological Sciences, Rutgers State University, New Brunswick, NJ, USA
5Scientelle, LLC, Morristown, NJ 07960, USA

Correspondence should be addressed to Michael L. Chikindas; ude.sregtur.posea@sadnikihct

Received 5 December 2017; Revised 12 March 2018; Accepted 23 May 2018; Published 2 July 2018

Academic Editor: Bryan Larsen

Copyright © 2018 Ammar Algburi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Infection recurrence and antibiotic resistance of bacterial vaginosis-associated pathogenic biofilms underline the need for novel and effective treatment strategies. In this study, we evaluated the antimicrobial, antibiofilm, and quorum sensing inhibitory effects of benzoyl peroxide and salicylic acid against Gardnerella vaginalis ATCC 14018, the predominant pathogen of bacterial vaginosis. While the highest tested concentrations of 250 and 125 μg/mL for both compounds were not sufficient in completely inhibiting the growth of G. vaginalis ATCC 14018, they did prevent biofilm formation by inhibiting the bacterial quorum sensing system in the pathogen. To our knowledge, this report is the first evidence that benzoyl peroxide can have a quorum sensing-mediated biofilm controlling effect, as demonstrated using subinhibitory concentrations of this compound in order to reduce the cost, dosage, and negative side effects associated with current antimicrobial treatments.