Infectious Diseases in Obstetrics and Gynecology

Research Article

Time-Kill Kinetics of Rezafungin (CD101) in Vagina-Simulative Medium for Fluconazole-Susceptible and Fluconazole-Resistant Candida albicans and Non-albicans Candida Species

Table 2

Summary of time-kill log-fold changes in CFU at 72 h.


Species	Strain	Suscept. to FLU (S/R)	Drug	Log-fold change in CFU at each drug conc. (μg/ml)
Species	Strain	Suscept. to FLU (S/R)	Drug	2	8	32	128

C. albicans	ATCC 44858	S	RZF	++
	ATCC 44858	S	TER	-	-	+	+
	DPL001	R	RZF
	DPL001	R	TER	-	-	-	-
	R357	R	RZF	+	++
	R357	R	TER	-	-	-	-

C. glabrata	CG01	S	RZF	+
	CG01	S	TER	-	-	-	-
	ATCC 200918	R	RZF
	ATCC 200918	R	TER	-	-	-	-
	MMX 7070	R	RZF			++
	MMX 7070	R	TER	-	-	-	-

C. tropicalis	CT02	S	RZF	-	++
	CT02	S	TER	-	-	-	+
	MMX 7255	R	RZF	++	+	++	++
	MMX 7255	R	TER	-	-	-	-
	MMX 7525	R	RZF
	MMX 7525	R	TER	-	-	-	-

C. parapsilosis	CP02	S	RZF	+	++	++
	CP02	S	TER	-	-	++	++
	CP01	R	RZF	-	++	++	++
	CP01	R	TER	-	-	-	-
	MMX 7370	R	RZF	-	+	+	++
	MMX 7370	R	TER	-	-	-	-

C. krusei	ATCC 6258	R	RZF
	ATCC 6258	R	TER	-	-	+
	ATCC 14243	R	RZF
	ATCC 14243	R	TER	-	-	-

Symbols denote log-fold changes in CFU from starting inoculum: increase or <1-log reduction (-); ≥1- to <2-fold reduction (+); ≥2- to <3-fold reduction in CFU (++); ≥3- to <4-fold reduction in CFU (+++); ≥4- to <5-fold reduction in CFU (++++). indicates fungicidal activity (≥3-log CFU reduction).