Total and Free 25-Hydroxy-Vitamin D and Bacterial Vaginosis in Pregnant African American Women

Table 4

Comparison of total and free 25-OH-D by Nugent Score category at study visits.

Vitamin D Measure (ng/mL)	Nugent Score Category			p-value for one-way ANOVA of group means
	Normal Flora	Intermediate Flora	BV
	n = 54	n = 26	n = 57
Visit 1
Total 25(OH)D
Median (IQR)	27.7 (10.0)	23.7 (12.7)	23.3 (10.1)	0.02
Min, Max	15.7, 40.9	10.4, 44.5	13.1, 43.7
Free 25(OH)D
Median (IQR)	3.8 (1.6)	4.1 (1.3)	3.7 (1.8)	0.75
Min, Max	1.4, 7.9	2.0, 6.3	1.4, 8.9
Visit 2
Total 25(OH)D
Median (IQR)	31.2 (13.4)	28.2 (13.5)	26.6 (9.9)	0.30
Min, Max	14.8, 53.9	14.4, 45.6	11.5, 44.6
Free 25(OH)D
Median (IQR)	4.0 (2.9)	4.0 (2.5)	3.9 (2.2)	0.69
Min, Max	1.2, 12.9	1.2, 8.3	1.5, 9.1
Visit 2-Visit 1
Δ Total 25(OH)D^1
Median (IQR)	5.0 (10.2)	2.4 (10.8)	1.2 (9.4)	0.003
Min, Max	-14.6, 5.0	-15.9, 18.0	-15.4, 11.0
Δ Free 25(OH)D^1
Median (IQR)	0.40 (1.5)	0.01 (1.9)	0.01 (1.6)	0.07
Min, Max	-2.1, 5.0	-3.6, 2.7	-3.0, 5.8

Bold, italic font, indicates a significant difference for women according to Nugent score category at α = 0.05.
¹ Change in 25(OH)D concentration from Visit 1 to Visit 2 (concentration at Visit 2—concentration at Visit 1).