Azithromycin in the Treatment of Preterm Prelabor Rupture of Membranes Demonstrates a Lower Risk of Chorioamnionitis and Postpartum Endometritis with an Equivalent Latency Period Compared with Erythromycin Antibiotic Regimens

Table 3

Crude and adjusted risk ratios for pregnancy outcomes for azithromycin versus erythromycin regimens.

	Crude			Adjusted
	RR	95% CI		RR	95% CI
Clinical chorioamnionitis	0.54	0.31 to 0.92	0.024	0.51	0.30 to 0.89	0.015
Histologic chorioamnionitis	1.07	0.82 to 1.41	0.604	1.08	0.82 to 1.43	0.569
Postpartum endometritis	0.48	0.29 to 0.79	0.004	0.46	0.27 to 0.76	0.002
Composite intra-amniotic infection/inflammation	0.92	0.73 to 1.18	0.523	0.92	0.72 to 1.18	0.524
Composite clinical infectious morbidity	0.50	0.35 to 0.73	<0.001	0.48	0.33 to 0.70	<0.001
Neonatal sepsis (positive blood culture)	0.33	0.14 to 0.77	0.010	0.32	0.14 to 0.76	0.005
Cesarean delivery	1.08	0.79 to 1.48	0.614	1.05	0.76 to 1.44	0.774
Meconium-stained amniotic fluid	1.73	1.05 to 2.85	0.031	1.69	1.01 to 2.81	0.042

Models were adjusted for maternal age, advanced maternal age, gestational age at diagnosis of PPROM, nulliparity, BMI, pregestational diabetes, group ß-streptococcus positive (bacteriuria), any hypertensive disorder in pregnancy, and race. ⁺ values calculated using the likelihood ratio test. Estimates are calculated via modified Poisson generalized linear models. RR = risk ratio; CI = confidence interval.