Infectious Diseases in Obstetrics and Gynecology / 2020 / Article / Tab 3

Research Article

Azithromycin in the Treatment of Preterm Prelabor Rupture of Membranes Demonstrates a Lower Risk of Chorioamnionitis and Postpartum Endometritis with an Equivalent Latency Period Compared with Erythromycin Antibiotic Regimens

Table 3

Crude and adjusted risk ratios for pregnancy outcomes for azithromycin versus erythromycin regimens.

CrudeAdjusted
RR95% CIRR95% CI

Clinical chorioamnionitis0.540.31 to 0.920.0240.510.30 to 0.890.015
Histologic chorioamnionitis1.070.82 to 1.410.6041.080.82 to 1.430.569
Postpartum endometritis0.480.29 to 0.790.0040.460.27 to 0.760.002
Composite intra-amniotic infection/inflammation0.920.73 to 1.180.5230.920.72 to 1.180.524
Composite clinical infectious morbidity0.500.35 to 0.73<0.0010.480.33 to 0.70<0.001
Neonatal sepsis (positive blood culture)0.330.14 to 0.770.0100.320.14 to 0.760.005
Cesarean delivery1.080.79 to 1.480.6141.050.76 to 1.440.774
Meconium-stained amniotic fluid1.731.05 to 2.850.0311.691.01 to 2.810.042

Models were adjusted for maternal age, advanced maternal age, gestational age at diagnosis of PPROM, nulliparity, BMI, pregestational diabetes, group ß-streptococcus positive (bacteriuria), any hypertensive disorder in pregnancy, and race. + values calculated using the likelihood ratio test. Estimates are calculated via modified Poisson generalized linear models. RR = risk ratio; CI = confidence interval.

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