Documented β-Lactam Allergy and Risk for Cesarean Surgical Site Infection

Table 3

Unadjusted and adjusted association between maternal and obstetric characteristics, including β-lactam allergy and surgical site infection.

Covariate	OR for SSI	value	aOR for SSI	value
β-Lactam allergy	2.13 (1.50-3.02)	<0.001	1.97 (1.24–3.14)	0.004
Age	0.97 (0.95-0.99)	0.004	0.98 (0.96–1.00)	0.104
Race
White	Ref		Ref
African American	1.36 (1.02-1.80)	0.033	1.26 (0.82–1.93)	0.290
Asian	1.05 (0.59-1.85)	0.865	1.49 (0.79–2.82)	0.217
Other	1.20 (0.53-2.74)	0.678	1.80 (0.77–4.22)	0.173
Multiracial	2.25 (0.70-7.21)	0.174	2.40 (0.69–8.37)	0.170
Ethnicity
Non-Hispanic	Ref		Ref
Hispanic	1.00 (0.79–1.27)	0.987	0.98 (0.66–1.47)	0.934
Insurance
Private	Ref		Ref
Public	1.32 (1.02–1.72)	0.036	1.25 (0.87–1.79)	0.217
None/other/unknown	0.76 (0.37–1.58)	0.462	0.78 (0.34–1.77)	0.559
Delivery BMI	1.04 (1.02-1.05)	<0.001	1.02 (1.00–1.04)	0.014
Smoking during pregnancy	0.71 (0.26–1.91)	0.496	0.48 (0.15–1.545)	0.221
Chorioamnionitis	2.84 (2.03-3.98)	<0.001	1.52 (0.98–2.35)	0.060
Duration of membrane rupture (min)	1.00 (0.99–1.00)	0.739	1.00 (0.99–1.00)	0.736
Preterm birth	1.67 (1.27–2.20)	<0.001	1.47 (1.06–2.05)	0.021
Cesarean indication
Scheduled	Ref		Ref
Unscheduled—fetal well-being related	1.89 (1.36-2.64)	<0.001	1.65 (1.13–2.41)	0.010
Unscheduled—labor related	4.64 (3.28-6.56)	<0.001	3.60 (2.39–5.42)	<0.001
Other	2.04 (1.49–2.80)	<0.001	1.93 (1.35–2.77)	<0.001
Pregestational diabetes	1.43 (0.87–2.35)	0.158	1.18 (0.68–2.03)	0.557
Gestational diabetes	1.15 (0.80–1.65)	0.441	1.01 (0.67–1.52)	0.960
Hypertension	2.17 (1.69–2.77)	<0.001	1.63 (1.21–2.18)	0.001
Group B Streptococcus colonization	0.70 (0.51–0.96)	0.030	0.69 (0.49–0.98)	0.039
β-Lactam received	0.77 (0.58–1.01)	0.060	0.95 (0.68–1.33)	0.778
Non-β-lactam received	2.46 (1.90–3.18)	<0.001	1.43 (1.01–2.02)	0.045