Research Article
Helicobacter pylori Exposure in Nausea and Vomiting of Pregnancy Increases Risk of Preterm Delivery
Figure 1
Vomiting in pregnancy and positive H. pylori testing results interact to predict risk of preterm delivery. (a) Among subjects in the University of Washington discovery cohort with vomiting in pregnancy, positive HP test result was associated with delivery at earlier gestational age (median 275 days versus 279 days). Hazard ratio and value represent the Mantel-Cox log rank test. (b) Pregnancy outcome ICD-10 codes were correlated to H. pylori test results (up to 5 years before pregnancy) and vomiting in pregnancy. Error bars represent 95% confidence intervals of the odds ratio, and absence of overlap with odds ratio 1 (dotted line) is considered statistically significant. Vomiting in pregnancy is associated with preterm labor, including 2nd trimester delivery. Positive HP tests are associated with preterm labor, both in the pregnant population as a whole and within the subset having vomiting in pregnancy (inset).
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