Simple Spectrophotometric Method for Determination of Paroxetine in Tablets Using 1,2-Naphthoquinone-4-Sulphonate as a Chromogenic Reagent

Table 1

Effect of diluting and extracting solvents on the intensity of the reaction product of PRX with NQS.

Diluting solvent	Absorbance(a)	Extracting solvent	Absorbance(a)
Methanol	0.802	Carbon tetrachloride	0.587
Ethanol	0.781	Chloroform	0.808
Isopropanol	0.778	Dichloromethane	0.716
Acetone	0.245	Ethyl acetate	0.362
Acetonitrile	0.686	Toluene	0.267
Dimethylformamide	0.346	Benzene	0.239
1,4-dioxane	0.617

(a)Values for all solvents are mean of three determinations; the RSDs for the readings were <3.