New Spectrophotometric and Fluorimetric Methods for Determination of Fluoxetine in Pharmaceutical Formulations

Table 5

Analysis of FLX in presence of common excipients by the proposed spectrophotometric and fluorimetric methods.

Excipient
	Recovery (% ± SD)(a)
	Spectrophotometric	Fluorimetric
	method	method
Starch (50)(b)	99.6±0.8	101.0±2.2
Glucose (10)	100.1±1.0	98.7±2.1
Lactose (10)	99.8±0.5	99.6±1.9
Acacia (10)	100.2±0.9	98.7±1.4
Talc (5)	99.6±1.0	99.4±1.3
MS(c) (10)	100.1±0.1	97.0±2.8
Average ± SD	99.9±0.4	99.1±1.3

(a)Values are mean of three determinations. (b)Figures in parenthesis are the amounts in mg added to 20 mg of FLX. (c)MS = Magnesium stearate.