New Spectrophotometric and Fluorimetric Methods for Determination of Fluoxetine in Pharmaceutical Formulations

Table 6

Determination of FLX in its pharmaceutical formulations (capsules) by the proposed spectrophotometric, fluorimetric and the official methods.

Capsules	Spectrophotometric method			Fluorimetric method
	Recovery (%) ± SD(a)	F value(b)	t value(b)	Recovery (%) ± SD(a)	F value(b)	t value(b)
Prozac	99.9±1.4	1.68	1.17	99.7±1.6	2.38	3.00
Pluzac	100.1±1.3	2.62	1.27	99.2±1.5	1.58	2.91
Salipax	99.8±1.3	1.00	1.10	100.8±1.8	1.60	2.18
Flutin	100.1±1.6	1.64	1.27	100.1±1.3	0.19	1.12
Octozac	99.8±1.2	2.35	2.13	99.4±1.5	1.49	2.47

(a)Values are mean of five determinations ± SD. (b)Theoretical values for t and F at 95% confidence limit (𝑛=5) were 2.78 and 6.39, respectively.