A Multidisciplinary Investigation to Determine the Structure and Source of Dimeric Impurities in AMG 517 Drug Substance

<table>Synthetic pathway of AMG 517 during the
early stages of clinical development.</table>

International Journal of Analytical Chemistry

Figure 2: A Multidisciplinary Investigation to Determine the Structure and Source of Dimeric Impurities in AMG 517 Drug Substance 